ArticleInternational journal of medical informatics2022
Alignment of two standard terminologies for dosage form: RxNorm from the National Library of Medicine for the United States and EDQM from the European Directorate for the Quality in Medicines and Healthcare for Europe.
Article in International journal of medical informatics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Advancing Global Harmonization: Implementing Global Dose Form Attributes for Medicinal Products Identification.Therapeutic innovation & regulatory science · 2025Article
- Semiautomatic mapping of a national drug terminology to standardised OMOP drug concepts using publicly available supplementary information.BMC medical research methodology · 2025Article
- Medicine Shortages: An Algorithm for Evaluating the Substitution with Equivalent or Alternative Products.Healthcare (Basel, Switzerland) · 2025Article
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Authors and funding
3 authors.
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Abstract
backgroundThere is currently no system that aligns pharmaceutically equivalent medicinal products across nations, creating obstacles to transnational medication prescribing and medical research. EDQM has been internationally recognized as the leading system in systematic pharmaceutical product descriptions. RxNorm is a critical terminology based in the US and used widely in applications internationally that would benefit from alignment with EDQM-based dosage form descriptions. GOAL: Demonstrate a method for alignment of RxNorm dosage forms with EDQM terminologies and with EDQM dosage forms. Describe obstacles and advantages of such an alignment for ultimate application in calculating universal Pharmaceutical Product Identifiers.
methodsA pharmaceutical sciences student and a clinical pharmacology expert in dosage forms used definitions supplied by RxNorm and EDQM technical documentation to align the 120 RxNorm dose forms to EDQM-based dosage form description terms. The alignment of RxNorm to EDQM was then used to fit the RxNorm dose forms into an ontology based on EDQM. RESULTS AND
conclusionsThe alignment of RxNorm and EDQM requires further validation but provides a potential method of establishing interoperability between the two terminologies without cumbersome manual reclassification. There remain ambiguities within each dosage form nomenclature that create obstacles to integrating medication databases rooted in EDQM and RxNorm into a single worldwide database.
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