ArticleVision research2022
Saccadic contributions to smooth pursuit in macular degeneration.
Article in Vision research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- The Limitations on Vergence Responses to Naturalistic Images Resulting From Simulated Central Scotomas and Defocused Peripheral Retina.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Article
- Cue combination for depth perception in macular degeneration: Motion parallax augments disparity.Journal of vision · 2026Article
- Reading Assessment and Eye Movement Analysis in Bilateral Central Scotoma Due to Age-Related Macular Degeneration.Journal of eye movement research · 2025Article
- Oculomotor challenges in macular degeneration impact motion extrapolation.Journal of vision · 2025Article
- Cancellation of the vestibulo-ocular reflex during smooth pursuit in patients with maculopathy.Frontiers in neurology · 2025Article
- Eye movements in visual impairment.Vision research · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Saccades during smooth pursuit can help bring the fovea on target, particularly in cases of low pursuit gain. Individuals with macular degeneration often suffer damage to the central retina including the fovea, which impacts oculomotor function such as fixation, saccadic and smooth pursuit eye movements. We hypothesized that these oculomotor changes in macular degeneration (MD) would make saccades less appropriately directed (even if more numerous). To investigate saccades during pursuit in MD, we conducted a quantitative analysis of smooth pursuit eye movement data from a prior study, Vision Research 141 (2017) 181-190. Here we examined saccade frequency, magnitude, and direction across viewing conditions for MD and control participants during pursuit of a target moving in a modified step-ramp paradigm. Individuals with MD had more variability in saccade directions that included directions orthogonal to the target trajectory. PRL eccentricity significantly correlated with increases in saccades in non-target directions during smooth pursuit. These results suggest that a large number of saccades during pursuit in MD participants are unlikely to be catch-up saccades that serve to keep the eye on the target.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.