Evidence map›Paper›PMID 35870126›Full record

ArticleTransplant infectious disease : an official journal of the Transplantation Society2022

Healthcare disparity and its associations with cytomegalovirus disease in pediatric liver transplant recipients in South Africa.

Priya Walabh, David P Moore, Graham Paget, Anja Meyer, Porai Nthabaleng M Moshesh, Pravina Walabh, Sechaba T Palweni, Christina Hajinicolaou

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PubMed Full text at PMC Publisher
In one paragraph

Article in Transplant infectious disease : an official journal of the Transplantation Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Healthcare disparity and its associations with cytomegalovirus disease in pediatric liver transplant recipients in South Africa.Transplant infectious disease : an official journal of the Transplantation Society · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Priya WalabhDepartment of Paediatrics and Child Health, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0003-4584-5958
David P MooreDepartment of Paediatrics and Child Health, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Graham PagetGauteng Provincial Solid Organ Transplant Division, Gauteng, South Africa.
Anja MeyerGauteng Provincial Solid Organ Transplant Division, Gauteng, South Africa.
Porai Nthabaleng M MosheshSchool of Clinical Medicine, Faculty of Health Sciences, Paediatric Intensive Care Unit, Nelson Mandela Children's Hospital, University of Witwatersrand, Johannesburg, South Africa.
Pravina WalabhUniversity of Cape Town, Cape Town, South Africa.
Sechaba T PalweniGauteng Provincial Solid Organ Transplant Division, Gauteng, South Africa.
Christina HajinicolaouDepartment of Paediatrics and Child Health, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
University of Cape Town · ZAUniversity of the Witwatersrand · ZASouth African Medical Research Council · ZA

Funding

No funding to declare for this study
6 · The paper itself

Abstract

backgroundCytomegalovirus (CMV) infection and disease are preventable complications following pediatric liver transplantation (PLT), despite the use of prophylaxis to minimize the risk of CMV disease. We evaluated the incidence and complications of CMV disease in PLT recipients in South Africa (SA), with particular reference to potential differences in outcome between state and private sector patients.

methodsMedical records of patients younger than 16 years of age who received liver transplants between January 1, 2012, and August 31, 2018 were analyzed.

resultsRecords of all 150 PLT patients were retrieved. The median age at transplant was 29.2 months (95% confidence interval 15.6-58.4) and follow-up was 46.3 months (interquartile range 27.6-63.1). Sixty-six (44%) patients were high risk, 79 (52.7%) were intermediate risk, and five (3.3%) were low risk for CMV infection. Forty-three (28.9%) patients had CMV DNAemia following transplantation, and 30 (20.1%) developed CMV disease. Receipt of care in the private sector was consistently associated with a lower hazard of CMV disease (adjusted hazard ratio [aHR] ranging from 0.36 to 0.43) and a consistently lower hazard of death among recipients at high risk for CMV disease and/or those who developed CMV disease (aHR ranging from 0.28 to 0.33).

conclusionReceipt of care in the private health sector was associated with a consistently lower hazard of CMV disease and death in individuals with CMV disease and/or at high risk for CMV disease. Policies aimed at creating a more equitable healthcare system in SA may mitigate the differential burden of illness associated with CMV in PLT recipients.

Indexed as

Cytomegalovirus InfectionsLiver TransplantationAntiviral AgentsChildChild, PreschoolCytomegalovirusGanciclovirHealthcare DisparitiesHumansRetrospective StudiesSouth AfricaTransplant RecipientsValganciclovirAntiviral AgentsGanciclovirValganciclovirend-organ diseaseequitable healthcareganciclovir prophylaxisimmunosuppressionmortalitypediatric liver transplantation

Identifiers

PMID35870126
PMCPMC10078342
OpenAlexW4286762111

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.