Evidence map›Paper›PMID 35870082›Full record

ArticleStem cell reviews and reports2022

Extracellular Adenosine (eAdo) - A

Arjun Thapa, Ahmed Abdelbaset-Ismail, Vira Chumak, Mateusz Adamiak, Katarzyna Brzezniakiewicz-Janus, Janina Ratajczak, Magdalena Kucia, Mariusz Z Ratajczak

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reviews and reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Arjun ThapaStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S. Floyd Street, Rm. 107, 40202, Louisville, KY, USA.
Ahmed Abdelbaset-IsmailStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S. Floyd Street, Rm. 107, 40202, Louisville, KY, USA.
Vira ChumakCenter for Preclinical Studies and Technology, Department of Regenerative Medicine, Medical University of Warsaw, Warsaw, Poland.
Mateusz AdamiakCenter for Preclinical Studies and Technology, Department of Regenerative Medicine, Medical University of Warsaw, Warsaw, Poland.
Katarzyna Brzezniakiewicz-JanusDepartment of Hematology, Multi-specialist Hospital Gorzow Wlkp, University of Zielona Gora, Zielona Gora, Poland.
Janina RatajczakStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S. Floyd Street, Rm. 107, 40202, Louisville, KY, USA.
Magdalena KuciaStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S. Floyd Street, Rm. 107, 40202, Louisville, KY, USA. mjkuci01@louisville.edu.
Mariusz Z RatajczakStem Cell Institute at James Graham Brown Cancer Center, University of Louisville, 500 S. Floyd Street, Rm. 107, 40202, Louisville, KY, USA. mzrata01@louisville.edu.ORCID http://orcid.org/0000-0002-0071-0198
University of Louisville · USMedical University of Warsaw · PLUniversity of Zielona Góra · PL

Funding

Novel mechanisms involving complement cascade in stem cell traffickingR01DK074720 · NIDDK · UNIVERSITY OF LOUISVILLE · PI RATAJCZAK, MARIUSZ Z · 2007 to 2020
$4.1M
Current Trends in Stem Cell TherapiesT32HL134644 · NHLBI · UNIVERSITY OF LOUISVILLE · PI KAKAR, SHAM S., RATAJCZAK, MARIUSZ Z · 2017 to 2021
$1.4M
NHLBI NIH HHS T32 HL134644NIDDK NIH HHS R01 DK074720
6 · The paper itself

Abstract

We postulated that mobilization, homing, and engraftment of hematopoietic stem/progenitor cells (HSCPs) is facilitated by a state of sterile inflammation induced in bone marrow (BM) after administration of pro-mobilizing drugs or in response to pre-transplant myeloablative conditioning. An important role in this phenomenon plays purinergic signaling that by the release of extracellular adenosine triphosphate (eATP) activates in HSPCs and in cells in the hematopoietic microenvironment an intracellular pattern recognition receptor (PPR) known as Nlrp3 inflammasome. We reported recently that its deficiency results in defective trafficking of HSPCs. Moreover, it is known that eATP after release into extracellular space is processed by cell surface expressed ectonucleotidases CD39 and CD73 to extracellular adenosine (eAdo) that in contrast to eATP shows an anti-inflammatory effect. Based on data that the state of sterile inflammation promotes trafficking of HSPCs, and since eAdo is endowed with anti-inflammatory properties we become interested in how eAdo will affect the mobilization, homing, and engraftment of HSPCs and which of eAdo receptors are involved in these processes. As expected, eAdo impaired HSPCs trafficking and this occurred in autocrine- and paracrine-dependent manner by direct stimulation of these cells or by affecting cells in the BM microenvironment. We report herein for the first time that this defect is mediated by activation of the A

Indexed as

InflammasomesAdenosineAnimalsHematopoietic Stem CellsInflammationMiceNLR Family, Pyrin Domain-Containing 3 ProteinAdenosineInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseAdenosinecAMPHeme oxygenase-1Innate immunityNlrp3 inflammasomeNRF-2P1 receptorsPurinergic signalingStem cell homing and engraftment

Identifiers

PMID35870082
PMCPMC9622533
OpenAlexW4286685052

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.