Evidence map›Paper›PMID 35870033›Full record

ArticlePurinergic signalling2023

NPP1 and TNAP hydrolyze ATP synergistically during biomineralization.

Luiz H S Andrilli, Heitor G Sebinelli, Bruno Z Favarin, Marcos A E Cruz, Ana Paula Ramos, Mayte Bolean, José Luis Millán, Massimo Bottini, Pietro Ciancaglini

Abstract read
In one paragraph

Article in Purinergic signalling, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. ENPP1 inhibition as a therapeutic approach for later-onset hypophosphatasia.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Bioinspired Collagen/κ-Carrageenan 3D Matrix forACS biomaterials science & engineering · 2025
    Article
  8. Taking a closer look at matrix vesicle biogenesis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Luiz H S AndrilliDepartment of Chemistry, FFCLRP- University of São Paulo, Ribeirão Preto, SP, Brazil.
Heitor G SebinelliDepartment of Chemistry, FFCLRP- University of São Paulo, Ribeirão Preto, SP, Brazil.
Bruno Z FavarinDepartment of Chemistry, FFCLRP- University of São Paulo, Ribeirão Preto, SP, Brazil.
Marcos A E CruzDepartment of Chemistry, FFCLRP- University of São Paulo, Ribeirão Preto, SP, Brazil.
Ana Paula RamosDepartment of Chemistry, FFCLRP- University of São Paulo, Ribeirão Preto, SP, Brazil.
Mayte BoleanDepartment of Chemistry, FFCLRP- University of São Paulo, Ribeirão Preto, SP, Brazil.
José Luis MillánSanford Burnham Prebys, La Jolla, San Diego, CA, USA.
Massimo BottiniDepartment of Chemistry, FFCLRP- University of São Paulo, Ribeirão Preto, SP, Brazil. massimo.bottini@uniroma2.it.
Pietro CiancagliniDepartment of Chemistry, FFCLRP- University of São Paulo, Ribeirão Preto, SP, Brazil. pietro@ffclrp.usp.br.ORCID 0000-0002-2785-1345

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Matrix vesicles (MVs) are a special class of extracellular vesicles released by mineralizing cells during bone and tooth mineralization that initiate the precipitation of apatitic minerals by regulating the extracellular ratio between inorganic phosphate (P

Indexed as

Alkaline PhosphataseCalcinosisAdenosine TriphosphateBiomineralizationBone and BonesHumansMineralsAdenosine TriphosphateAlkaline PhosphataseMineralsNPP1PhosphohydrolaseProteoliposomesPyrophosphohydrolaseTNAP

Identifiers

PMID35870033
PMCPMC10247588

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.