Evidence map›Paper›PMID 35869995›Full record

ArticleJournal of neurology2022

Characteristic retinal atrophy pattern allows differentiation between pediatric MOGAD and MS after a single optic neuritis episode.

T Pakeerathan, J Havla, C Schwake, A Salmen, S Bigi, M Abegg, D Brügger, T Ferrazzini, A-K Runge, M Breu and 15 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. MOG Antibody Disease: Nuances in Presentation, Diagnosis, and Management.Current neurology and neuroscience reports · 2024
    Review
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 9 institutions in 4 countries.

T PakeerathanDepartment of Neurology, St. Josef-Hospital, Ruhr-University Bochum, 44791, Bochum, Germany.
J HavlaInstitute of Clinical Neuroimmunology, LMU Hospital, Ludwig-Maximilians Universität München, Munich, Germany.
C SchwakeDepartment of Neurology, St. Josef-Hospital, Ruhr-University Bochum, 44791, Bochum, Germany.
A SalmenDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
S BigiDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
M AbeggDepartment of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
D BrüggerDepartment of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
T FerrazziniDepartment of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
A-K RungeDepartment of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
M BreuDivision of Pediatric Pulmonology, Allergology and Endocrinology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.
B KornekDepartment of Neurology, Medical University of Vienna, Vienna, Austria.
G BstehDepartment of Neurology, Medical University of Vienna, Vienna, Austria.
A Felipe-RuciánDepartment of Pediatric Neurology, Universitat Autònoma de Barcelona, Vall d'Hebron Hospital, Barcelona, Spain.
M RingelsteinDepartment of Neurology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
O AktasDepartment of Neurology, Medical Faculty, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
M KarenfortDepartment of General Paediatrics, Neonatology and Paediatric Cardiology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany.
E WendelDepartment of Pediatric Neurology, Olgahospital, Stuttgart, Germany.
I KleiterDepartment of Neurology, St. Josef-Hospital, Ruhr-University Bochum, 44791, Bochum, Germany.
K HellwigDepartment of Neurology, St. Josef-Hospital, Ruhr-University Bochum, 44791, Bochum, Germany.
T KümpfelInstitute of Clinical Neuroimmunology, LMU Hospital, Ludwig-Maximilians Universität München, Munich, Germany.
C ThielsDepartment of Neuropediatrics, University Children's Hospital, Ruhr-University, Bochum, Germany.
T LückeDepartment of Neuropediatrics, University Children's Hospital, Ruhr-University, Bochum, Germany.
R GoldDepartment of Neurology, St. Josef-Hospital, Ruhr-University Bochum, 44791, Bochum, Germany.
K RostasyDepartment of Pediatric Neurology, Children's Hospital Datteln, University Witten/Herdecke, Witten, Germany.
I AyzenbergDepartment of Neurology, St. Josef-Hospital, Ruhr-University Bochum, 44791, Bochum, Germany. ilya.ayzenberg@rub.de.ORCID http://orcid.org/0000-0002-6009-792X
University of Bern · CHSt. Josef-Hospital · DEHeinrich Heine University Düsseldorf · DEMedical University of Vienna · ATUniversity Hospitals of the Ruhr-University of Bochum · DELudwig-Maximilians-Universität München · DEOlgahospital · DEUniversitat Autònoma de Barcelona · ESWitten/Herdecke University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOptic neuritis (ON) is the most prevalent manifestation of pediatric multiple sclerosis (MS

methodsPatients were retrospectively identified in eight tertial referral centers. OCT, VEP and high/low-contrast visual acuity (HCVA/LCVA) have been investigated > 6 months after the first ON. Prevalence of pathological OCT findings was identified based on data of 144 age-matched healthy controls.

resultsThirteen MOGAD

conclusionFirst MOGAD-ON results in a more severe global peripapillary atrophy compared to predominantly temporal thinning in MS-ON. Nasal pRNFL allows differentiation between both diseases with the highest accuracy, supporting the additional diagnostic value of OCT in children with ON.

Indexed as

Multiple SclerosisOptic NeuritisRetinal DegenerationAtrophyHumansRetinaRetrospective StudiesTomography, Optical CoherenceVision DisordersChildrenMOGADMultiple sclerosisMyelin-oligodendrocyte-glycoprotein IgGOptical coherence tomographyOptic neuritisPediatric patientsVisual evoked potential

Identifiers

PMID35869995
PMCPMC9618526
OpenAlexW4286685211

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.