ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2022
[Down-regulation of SIK2 expression alleviates myocardial ischemia-reperfusion injury in rats by inhibiting autophagy through the mTOR-ULK1 signaling pathway].
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- [Colchicine alleviates myocardial ischemia-reperfusion injury in mice by activating AMPK].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2024Article
- Understanding the roles of salt-inducible kinases in cardiometabolic disease.Frontiers in physiology · 2024Review
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6 authors at 1 institution in 1 country.
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Abstract
objectiveTo explore the role of salt-inducible kinase 2 (SIK2) in myocardial ischemia-reperfusion (IR) injury in rats.
methodsFifteen male SD rats were randomized equally into sham operation group, myocardial IR model group, and SIK2 inhibitor group (in which the rats were treated with intravenous injection of 10 mg/kg bosutinib
resultsMyocardial IR injury significantly increased the number of autophagosomes (P < 0.05) and the expression of SIK2 protein (
conclusionSIK2 may promote autophagy through the mTOR/ULK1 signaling pathway, and inhibiting SIK2 can reduce abnormal autophagy and alleviate myocardial IR injury in rats.
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