ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2022
[Association between coagulation function and prognosis in patients with acute pancreatitis].
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 3 citations in OpenAlex.
- A Novel Triple-Biomarker Score Predicts Mortality in Acute Pancreatitis.Gastroenterology research · 2026Article
- A new in-hospital mortality prediction nomogram for intensive care unit patients with acute pancreatitis.Archives of medical science : AMS · 2024Article
- Establishment and Validation of an Early Predictive Model for Severe Acute Pancreatitis.Journal of inflammation research · 2024Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
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Abstract
objectiveTo explore the correlation of coagulation function with the severity and prognosis of acute pancreatitis (AP) and identify the laboratory markers for early prediction and dynamic monitoring of the prognosis of AP.
methodsWe retrospectively analyzed the clinical data of patients with AP admitted less than 72 h after onset to our hospital from December 1, 2017 to November 30, 2018. The correlation of coagulation function-related markers at admission and their changes during hospitalization with the prognosis of the patients was analyzed.
resultsWe screened the data of a total of 1260 patients with AP against the inclusion and exclusion criteria, and eventually 175 patients were enrolled in this analysis, among whom 52 patients had severe AP (SAP) and 12 patients died. Logistic regression analysis identified vWF: Ag, PT, PC, AT Ⅲ and D-dimer markers at admission as independent risk factors for predicting SAP and death. Dynamic monitoring of the changes in coagulation function-related markers in the disease course had greater predictive value of the patients' prognosis, and the indicators including vWF: Ag
conclusionPatients with AP have vascular endothelial injuries and coagulation disorders. The markers including vWF: Ag, PT, PC, AT Ⅲ and D-dimer at admission are independent risk factors for predicting SAP and death, and dynamic monitoring of the changes in vWF: Ag、PT、APTT、TT、FIB、D-dimer、PLT、PC、AT Ⅲ and PLG can further increase the predictive value.
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