Evidence map›Paper›PMID 35869550›Full record

ArticleLipids in health and disease2022

Association between the atherogenic index of plasma and major adverse cardiovascular events among non-diabetic hypertensive older adults.

Fei Hang, Jieruo Chen, Zefeng Wang, Keyang Zheng, Yongquan Wu

Abstract read
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In one paragraph

Article in Lipids in health and disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fei HangDepartment of Cardiology, Beijing Anzhen hospital, Capital Medical University, No.2 Anzhen Road, Beijing, 100029, China.
Jieruo ChenDepartment of Cardiology, Beijing Anzhen hospital, Capital Medical University, No.2 Anzhen Road, Beijing, 100029, China.
Zefeng WangDepartment of Cardiology, Beijing Anzhen hospital, Capital Medical University, No.2 Anzhen Road, Beijing, 100029, China.
Keyang ZhengDepartment of Cardiology, Beijing Anzhen hospital, Capital Medical University, No.2 Anzhen Road, Beijing, 100029, China.
Yongquan WuDepartment of Cardiology, Beijing Anzhen hospital, Capital Medical University, No.2 Anzhen Road, Beijing, 100029, China. wuyongquan_anzhen@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLiterature on the association between the atherogenic index of plasma (AIP) and the risk of major adverse cardiovascular events (MACEs) among non-diabetic hypertensive older adults is quite limited.

methodsA post-hoc analysis of data obtained from the Systolic Blood Pressure Intervention Trial was performed. The predictive value of AIP on the risk of MACEs among non-diabetic hypertensive older adults was assessed to evaluate whether the benefit of intensive blood pressure (BP) control in preventing MACEs is consistent in different AIP subgroups.

resultsIn this study, 9323 participants with AIP were included, out of which 561 (6.02%) had composite cardiovascular outcomes during a median of 3.22 years of follow-up. Patients in the highest AIP quartile had a significantly increased risk of the primary outcome. In the fully adjusted Model 3, the adjusted hazard ratios (HRs) of the primary outcome for participants in Q2, Q3, and Q4 of AIP were 1.32 (1.02, 1.72), 1.38 (1.05, 1.81), and 1.56 (1.17, 2.08) respectively. Consistently, the trend test for the association between AIP quartiles and the primary outcome showed that a higher AIP quartile was associated with a significantly higher risk of the primary outcome (adjusted HR (95%CI) in model 3:1.14 (1.04, 1.25), P = 0,004). However, within each AIP quartile, absolute event rates were lower in the intensive treatment group. No evidence was found for the interaction between intensive BP control and AIP for the risk of the primary outcome (P for interaction = 0.932).

conclusionThis study found that elevated AIP was independently and positively associated with the risk of MACEs among non-diabetic hypertensive older adults. The benefits of intensive BP control in managing cardiovascular events were consistent in different AIP subgroups.

Indexed as

HypertensionAgedBlood PressureHumansRisk FactorsAtherogenic index of plasmaHypertensionIntensive blood pressure managementMajor adverse cardiovascular events

Identifiers

PMID35869550
PMCPMC9308240

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.