Evidence map›Paper›PMID 35869480›Full record

ArticleBMC musculoskeletal disorders2022

Apparent diffusion coefficient values in Modic changes - interobserver reproducibility and relation to Modic type.

Magnhild H Dagestad, Nils Vetti, Per M Kristoffersen, John-Anker Zwart, Kjersti Storheim, Gunnstein Bakland, Jens I Brox, Lars Grøvle, Gunn H Marchand, Erling Andersen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Magnhild H DagestadDepartment of Radiology, Haukeland University Hospital, Jonas Liesvei 65, 5021, Bergen, Norway. magnhild.hammersland.dagestad@helse-bergen.no.
Nils VettiDepartment of Radiology, Haukeland University Hospital, Jonas Liesvei 65, 5021, Bergen, Norway.
Per M KristoffersenDepartment of Radiology, Haukeland University Hospital, Jonas Liesvei 65, 5021, Bergen, Norway.
John-Anker ZwartResearch and Communication Unit for Musculoskeletal Health (FORMI), Division of Neuroscience, Oslo University Hospital HF, Ulleval, Bygg 37b, P.O. Box 4956, Nydalen, 0424, Oslo, Norway.
Kjersti StorheimResearch and Communication Unit for Musculoskeletal Health (FORMI), Division of Neuroscience, Oslo University Hospital HF, Ulleval, Bygg 37b, P.O. Box 4956, Nydalen, 0424, Oslo, Norway.
Gunnstein BaklandDepartment of Rheumatology, University Hospital of North Norway, P.O. Box 100, 9038, Tromsø, Norway.
Jens I BroxFaculty of Medicine, University of Oslo, P.O. Box 1072 Blindern, 0316, Oslo, Norway.
Lars GrøvleDepartment of Rheumatology, Østfold Hospital Trust, P.O. Box 300, 1714 Grålum, Moss, Norway.
Gunn H MarchandDepartement of Physical Medicine and Rehabilitation, St. Olavs Hospital, Trondheim University Hospital, P.O. Box 3250 Torgarden, 7006, Trondheim, Norway.
Erling AndersenDepartment of Clinical Engineering, Haukeland University Hospital, P.O. Box 1400, 5021, Bergen, Norway.
Jörg AssmusCentre for Clinical Research, Haukeland University Hospital, Jonas Liesvei 65, 5021, Bergen, Norway.
Ansgar EspelandDepartment of Radiology, Haukeland University Hospital, Jonas Liesvei 65, 5021, Bergen, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundModic Changes (MCs) in the vertebral bone marrow were related to back pain in some studies but have uncertain clinical relevance. Diffusion weighted MRI with apparent diffusion coefficient (ADC)-measurements can add information on bone marrow lesions. However, few have studied ADC measurements in MCs. Further studies require reproducible and valid measurements. We expect valid ADC values to be higher in MC type 1 (oedema type) vs type 3 (sclerotic type) vs type 2 (fatty type). Accordingly, the purpose of this study was to evaluate ADC values in MCs for interobserver reproducibility and relation to MC type.

methodsWe used ADC maps (b 50, 400, 800 s/mm

resultsThe 90 patients (mean age 44 years; 54 women) had 224 MCs Th12-S1 comprising type 1 (n = 111), type 2 (n = 91) and type 3 MC groups (n = 22). All ADC variables had higher predicted mean for type 1 vs 3 vs 2 (p < 0.001 to 0.02): MC-ADC (10

conclusionsThe MC-ADC variable (highest mean ADC in the MC) had best interobserver reproducibility, discriminated between MC type groups, and may be used in further research. ADC values differed between MC types as expected from previously reported MC histology.

Indexed as

Bone DiseasesLow Back PainAdultDiffusion Magnetic Resonance ImagingFemaleHumansMagnetic Resonance ImagingReproducibility of ResultsROC CurveAdultsImaging sequencesMR-imagingObserver performanceSkeletal-axialSpine

Identifiers

PMID35869480
PMCPMC9306145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.