ArticleBMC anesthesiology2022
Changes in mean systemic filling pressure as an estimate of hemodynamic response to anesthesia induction using propofol.
Article in BMC anesthesiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07028593 (Effects of Ciprofol on Myocardial Injury After Non-cardiac Surgery), which is not on this map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Ciprofol on Myocardial Injury After Non-cardiac Surgery (CP-MINS) in Patients Undergoing Video-Assisted Thoracoscopic Surgery: A Randomized, Double-Blind, Propofol-Controlled, Multicenter Trial
Who cites it
7 citing papers in PubMed.
- Venous excess ultrasound: A mini-review and practical guide for its application in critically ill patients.World journal of critical care medicine · 2025Review
- Right ventricle and venous system: bridging physiology and clinical practice. A narrative review.Critical care science · 2025Review
- Pharmacodynamic Model of the Hemodynamic Effects of Propofol and Remifentanil and Their Interaction with Noxious Stimulation.Pharmaceutics · 2024Article
- Sensitivity analysis of closed-loop one-chamber and four-chamber models with baroreflex.PLoS computational biology · 2024Article
- Venous return physiology applied to post-cardiac arrest haemodynamic management: a post hoc analysis of the NEUROPROTECT trial.Intensive care medicine experimental · 2024Article
- Perioperative management of the vulnerable and failing right ventricle.Perioperative medicine (London, England) · 2024Review
- Anaesthetic management of colorectal surgery in a patient with chronic pericardial effusion.Anaesthesia reportsArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEven a small change in the pressure gradient between the venous system and the right atrium can have significant hemodynamic effects. Mean systemic filling pressure (MSFP) is the driving force of the venous system. As a result, MSFP has a significant effect on cardiac output. We aimed to test the hypothesis that the hemodynamic instability during induction of general anesthesia by intravenous propofol administration is caused by changes in MSFP.
methodsWe prospectively collected data from 15 patients undergoing major surgery requiring invasive hemodynamic monitoring. Hemodynamic parameters, including MSFP, were measured before and after propofol administration and following intubation, using venous return curves at a no-flow state induced by a pneumatic tourniquet.
resultsA significant decrease in MSFP was observed in all study patients after propofol administration (median (IQR) pressure 17 (9) mmHg compared with 25 (7) before propofol administration, p = 0.001). The pressure gradient for venous return (MSFP - central venous pressure; CVP) also decreased following propofol administration from 19 (8) to 12 (6) mmHg, p = 0.001. Central venous pressure did not change.
conclusionsThese results support the hypothesis that induction of anesthesia with propofol causes a marked reduction in MSFP. A possible mechanism of propofol-induced hypotension is reduction in preload due to a decrease in the venous vasomotor tone.
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