Evidence map›Paper›PMID 35869291›Full record

ReviewNeuroradiology2022

2021 WHO classification of tumours of the central nervous system: a review for the neuroradiologist.

Cillian McNamara, Kshitij Mankad, Stefanie Thust, Luke Dixon, Clara Limback-Stanic, Felice D'Arco, Thomas S Jacques, Ulrike Löbel

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neuroradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cillian McNamaraDepartment of Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. cillian.mcnamara@nhs.net.ORCID http://orcid.org/0000-0001-8164-7794
Kshitij MankadDepartment of Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Stefanie ThustDepartment of Neuroradiology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
Luke DixonDepartment of Neuroradiology, Imperial College Healthcare NHS Trust, London, UK.
Clara Limback-StanicDepartment of Cellular Pathology, Imperial College Healthcare NHS Trust, London, UK.
Felice D'ArcoDepartment of Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Thomas S JacquesDBC Programme, UCL GOS Institute of Child Health and Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
Ulrike LöbelDepartment of Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The fifth edition of the World Health Organization Classification of Tumours of the Central Nervous System (WHO CNS5) published in 2021 builds on the 2016 edition and incorporates output from the Consortium to Inform Molecular and Practical Approaches to CNS Tumour Taxonomy (cIMPACT-NOW). WHO CNS5 introduces fundamental changes to brain tumour classification through the introduction of new tumour families and types, especially in the paediatric population, and a revision of diagnostic criteria for some of the existing neoplasms. Neuroradiologists are central to brain tumour diagnostics, and it is therefore essential that they become familiar with the key updates. This review aims to summarise the most relevant updates for the neuroradiologist and, where available, discuss the known radiophenotypes of various new tumour types to allow for increased accuracy of language and diagnosis. Of particular importance, WHO CNS5 places greater emphasis on organising tumours by molecular type to reflect biology, as well as to allow for better planning of treatment. The principal updates in adult tumours concern the molecular definition of glioblastoma, restructuring of diffuse gliomas, and the introduction of several new tumour types. The updates to the paediatric classification are protean, ranging from the introduction of new types to establishing separate tumour families for paediatric-type gliomas. This review summarises the most significant revisions and captures the rationale and radiological implications for the major updates.

Indexed as

Brain NeoplasmsCentral Nervous System NeoplasmsGliomaBrainChildHumansWorld Health OrganizationBrain tumourCentral nervous systemClassificationDiagnosisWorld Health Organization

Identifiers

PMID35869291

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.