ArticleMolecular psychiatry2022
Altered neural flexibility in children with attention-deficit/hyperactivity disorder.
Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Interaction of artificial intelligence, mental disorders, and diverse data modalities: Potential treatment management based on the "method-disease-data" axis.Neural regeneration research · 2026Article
- Dopamine-related alterations in functional brain network dynamic reconfiguration in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Altered flow of information in attention-deficit/hyperactivity disorder.Translational psychiatry · 2026Article
- Methylphenidate stabilizes dynamic brain network organization during tasks probing attention and reward processing in stimulant-naïve children with ADHD.Translational psychiatry · 2025Article
- Neural flexibility is higher in Alzheimer's disease and predicts Alzheimer's disease transition.Journal of Alzheimer's disease : JAD · 2025Article
- Aberrant Modular Dynamics of Functional Networks in Schizophrenia and Their Relationship With Neurotransmitter and Gene Expression Profiles.Human brain mapping · 2025Article
- Charting brain functional development from birth to 6 years of age.Nature human behaviour · 2025Article
- Twenty-Four-Hour Movement Behaviors and Social Functions in Neurodiverse Children: A Scoping Review.Behavioral sciences (Basel, Switzerland) · 2025Review
- Aberrant Flexibility of Dynamic Brain Network in Patients with Autism Spectrum Disorder.Bioengineering (Basel, Switzerland) · 2024Article
- Controllability in attention deficit hyperactivity disorder brains.Cognitive neurodynamics · 2024Article
- Different brain functional network abnormalities between attention-deficit/hyperactivity disorder youth with and without familial risk for bipolar disorder.European child & adolescent psychiatry · 2024Article
- Altered neurovascular coupling in the children with attention-deficit/hyperactivity disorder: a comprehensive fMRI analysis.European child & adolescent psychiatry · 2024Article
- The contributions of neonatal inhalation of copper to air pollution-induced neurodevelopmental outcomes in mice.Neurotoxicology · 2024Article
- Machine Learning Techniques to Predict Mental Health Diagnoses: A Systematic Literature Review.Clinical practice and epidemiology in mental health : CP & EMH · 2024Review
- How brain networks tic: Predicting tic severity through rs-fMRI dynamics in Tourette syndrome.Human brain mapping · 2023Article
- Distinct Frontoparietal Brain Dynamics Underlying the Co-Occurrence of Autism and ADHD.eNeuro · 2023Article
- Trait absorption is not reliably associated with brain structure or resting-state functional connectivity.Neuroimage. Reports · 2023Article
- A Review of Machine Learning and Deep Learning Approaches on Mental Health Diagnosis.Healthcare (Basel, Switzerland) · 2023Review
- Ensemble Model for Diagnostic Classification of Alzheimer's Disease Based on Brain Anatomical Magnetic Resonance Imaging.Diagnostics (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Attention-deficit/hyperactivity disorder (ADHD) is one of the most common neurodevelopmental disorders of childhood, and is often characterized by altered executive functioning. Executive function has been found to be supported by flexibility in dynamic brain reconfiguration. Thus, we applied multilayer community detection to resting-state fMRI data in 180 children with ADHD and 180 typically developing children (TDC) to identify alterations in dynamic brain reconfiguration in children with ADHD. We specifically evaluated MR derived neural flexibility, which is thought to underlie cognitive flexibility, or the ability to selectively switch between mental processes. Significantly decreased neural flexibility was observed in the ADHD group at both the whole brain (raw p = 0.0005) and sub-network levels (p < 0.05, FDR corrected), particularly for the default mode network, attention-related networks, executive function-related networks, and primary networks. Furthermore, the subjects with ADHD who received medication exhibited significantly increased neural flexibility (p = 0.025, FDR corrected) when compared to subjects with ADHD who were medication naïve, and their neural flexibility was not statistically different from the TDC group (p = 0.74, FDR corrected). Finally, regional neural flexibility was capable of differentiating ADHD from TDC (Accuracy: 77% for tenfold cross-validation, 74.46% for independent test) and of predicting ADHD severity using clinical measures of symptom severity (R
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.