ArticleScientific reports2022
Non-random genetic alterations in the cyanobacterium Nostoc sp. exposed to space conditions.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Design and dynamics of space- station-based one-degree-of-freedom repeatedly deployable exposure platform.iScience · 2025Article
- Nucleic acid amplification tests in digital microfluidics: the promise of next-generation point-of-care diagnostics.Microsystems & nanoengineering · 2025Review
- Exploring organic compound preservation through long-term in situ experiments in the Atacama desert and the relevance for Mars.Scientific reports · 2025Article
- The role of the protective shield against UV-C radiation and its molecular interactions in Nostoc species (Cyanobacteria).Scientific reports · 2024Article
- Lab-on-chip technologies for space research - current trends and prospects.Mikrochimica acta · 2023Review
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Authors and funding
12 authors.
Funding
Abstract
Understanding the impact of long-term exposure of microorganisms to space is critical in understanding how these exposures impact the evolution and adaptation of microbial life under space conditions. In this work we subjected Nostoc sp. CCCryo 231-06, a cyanobacterium capable of living under many different ecological conditions, and also surviving in extreme ones, to a 23-month stay at the International Space Station (the Biology and Mars Experiment, BIOMEX, on the EXPOSE-R2 platform) and returned it to Earth for single-cell genome analysis. We used microfluidic technology and single cell sequencing to identify the changes that occurred in the whole genome of single Nostoc cells. The variant profile showed that biofilm and photosystem associated loci were the most altered, with an increased variant rate of synonymous base pair substitutions. The cause(s) of these non-random alterations and their implications to the evolutionary potential of single bacterial cells under long-term cosmic exposure warrants further investigation.
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