ArticleNPJ digital medicine2022
Age estimation from sleep studies using deep learning predicts life expectancy.
Article in NPJ digital medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Electronic Media Use and Sleep Quality: Updated Systematic Review and Meta-Analysis.Journal of medical Internet research · 2024Pooled it
- A foundation model for sleep-based risk stratification and clinical outcomes.Nature communications · 2026Article
- Predictor of Mortality in Obstructive Sleep Apnea: Results of Explainable Deep Learning-Based Survival Analysis from a 15-Year Follow-Up.Respiration; international review of thoracic diseases · 2026Article
- SleepJEPA: Learning the latent world of sleep with at-home sleep data to estimate disease risk.medRxiv : the preprint server for health sciences · 2026Article
- Brain Health from Sleep EEG: A Multicohort, Deep Learning Biomarker for Cognition, Disease, and Mortality.NEJM AI · 2026Article
- A multimodal sleep foundation model for disease prediction.Nature medicine · 2026Article
- PhysioJEPA: Joint Embedding Representations of Physiological Signals for Real Time Risk Estimation in the Intensive Care Unit.Proceedings of machine learning research · 2025Article
- Decoding brain age predictions from sleep electroencephalography across infancy to adolescence.Scientific reports · 2025Article
- A wearable-based aging clock associates with disease and behavior.Nature communications · 2025Observational
- [Research progress in electroencephalogram-based brain age prediction].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025Review
- Article
- Article
- A Multimodal Sleep Foundation Model Developed with 500K Hours of Sleep Recordings for Disease Predictions.medRxiv : the preprint server for health sciences · 2025Article
- An Artificial Intelligence-Based Non-Invasive Approach for Cardiovascular Disease Risk Stratification in Obstructive Sleep Apnea Patients: A Narrative Review.Reviews in cardiovascular medicine · 2024Review
- Influence of sleep on physiological systems in atherosclerosis.Nature cardiovascular research · 2024Review
- Strengths, weaknesses, opportunities, and threats of using AI-enabled technology in sleep medicine: a commentary.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Review
- UltraAIGenomics: Artificial Intelligence-Based Cardiovascular Disease Risk Assessment by Fusion of Ultrasound-Based Radiomics and Genomics Features for Preventive, Personalized and Precision Medicine: A Narrative Review.Reviews in cardiovascular medicine · 2024Review
- Achieving Better Understanding of Obstructive Sleep Apnea Treatment Effects on Cardiovascular Disease Outcomes through Machine Learning Approaches: A Narrative Review.Journal of clinical medicine · 2024Review
- Brain Age Estimation from Overnight Sleep Electroencephalography with Multi-Flow Sequence Learning.Nature and science of sleep · 2024Article
- Do try this at home: Age prediction from sleep and meditation with large-scale low-cost mobile EEG.Imaging neuroscience (Cambridge, Mass.) · 2024Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Sleep disturbances increase with age and are predictors of mortality. Here, we present deep neural networks that estimate age and mortality risk through polysomnograms (PSGs). Aging was modeled using 2500 PSGs and tested in 10,699 PSGs from men and women in seven different cohorts aged between 20 and 90. Ages were estimated with a mean absolute error of 5.8 ± 1.6 years, while basic sleep scoring measures had an error of 14.9 ± 6.29 years. After controlling for demographics, sleep, and health covariates, each 10-year increment in age estimate error (AEE) was associated with increased all-cause mortality rate of 29% (95% confidence interval: 20-39%). An increase from -10 to +10 years in AEE translates to an estimated decreased life expectancy of 8.7 years (95% confidence interval: 6.1-11.4 years). Greater AEE was mostly reflected in increased sleep fragmentation, suggesting this is an important biomarker of future health independent of sleep apnea.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.