ArticleCommunications biology2022
Cross-species experiments reveal widespread cochlear neural damage in normal hearing.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Is Noise Exposure Associated With Impaired Extended High Frequency Hearing Despite a Normal Audiogram? A Systematic Review and Meta-Analysis.Trends in hearingPooled it
- Comparing physiological signatures of synaptopathic noise exposure and carboplatin-induced inner-hair-cell dysfunction in chinchillas.Hearing research · 2026Article
- Short-term test-retest reliability of a few proxy measures of cochlear synaptopathy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Parallel Age-Related Cochlear Neural Degeneration and Cortical Gain Adaptation in Normal-Hearing Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Differentiating the Physiological Signatures of Cochlear Synaptopathy and Inner Hair Cell Damage in a Chinchilla Model.bioRxiv : the preprint server for biology · 2026Article
- Cochlear histopathology in macaques after noise-induced temporary threshold shifts.Hearing research · 2026Article
- On the Sharpness of Auditory Filters: Considering Subclinical Deficits Reveals Sharper Otoacoustic Emission Estimates of Frequency Selectivity in Humans.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- The Effects of Broadband Elicitor Duration on Transient-Evoked Otoacoustic Emissions and a Psychoacoustic Measure of Gain Reduction.Journal of the Association for Research in Otolaryngology : JARO · 2025Article
- Article
- Effect of digital noise reduction processing on subcortical speech encoding and relationship to behavioral outcomes.Scientific reports · 2025Article
- Associations between physiological indicators of cochlear deafferentation and listening effort in military Veterans with normal audiograms.Hearing research · 2025Article
- Test-Retest Differences in the Wideband Middle Ear Muscle Reflex.American journal of audiology · 2025Article
- The relationship between distortion product otoacoustic emissions and audiometric thresholds in the extended high-frequency range.The Journal of the Acoustical Society of America · 2025Article
- Sound Advice: A Consumer's Perspective on Navigating the World of Over-the-Counter Hearing Aids.Seminars in hearing · 2025Review
- Unravelling hidden hearing loss.eLife · 2024Article
- Effect of digital noise-reduction processing on subcortical speech encoding and relationship to behavioral outcomes.bioRxiv : the preprint server for biology · 2024Article
- The relationship between distortion product otoacoustic emissions and audiometric thresholds in the extended high-frequency range.bioRxiv : the preprint server for biology · 2024Article
- A multi-channel EEG mini-cap can improve reliability for recording auditory brainstem responses in chinchillas.Journal of neuroscience methods · 2023Article
- A data-driven approach to identify a rapid screener for auditory processing disorder testing referrals in adults.Scientific reports · 2023Article
- The effects of broadband elicitor duration on a psychoacoustic measure of cochlear gain reduction.The Journal of the Acoustical Society of America · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Animal models suggest that cochlear afferent nerve endings may be more vulnerable than sensory hair cells to damage from acoustic overexposure and aging. Because neural degeneration without hair-cell loss cannot be detected in standard clinical audiometry, whether such damage occurs in humans is hotly debated. Here, we address this debate through co-ordinated experiments in at-risk humans and a wild-type chinchilla model. Cochlear neuropathy leads to large and sustained reductions of the wideband middle-ear muscle reflex in chinchillas. Analogously, human wideband reflex measures revealed distinct damage patterns in middle age, and in young individuals with histories of high acoustic exposure. Analysis of an independent large public dataset and additional measurements using clinical equipment corroborated the patterns revealed by our targeted cross-species experiments. Taken together, our results suggest that cochlear neural damage is widespread even in populations with clinically normal hearing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.