ArticleScientific reports2022
Molecular docking analysis and evaluation of the antimicrobial properties of the constituents of Geranium wallichianum D. Don ex Sweet from Kashmir Himalaya.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed.
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- Antagonistic activity of butanamine 2,2-dinitro-N-methyl- synthesized by endosymbiotic Bacillus amyloliquefaciens VITAPRJS1 acquired from horse milk.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- GC-MS profiling, in vitro and in silico antibacterial and antioxidant potential of crude secondary metabolites of an endophytic bacterium isolated from Enhydra fluctuans lour.Scientific reports · 2025Article
- Elucidating chromosomal ARGs in environmental Aeromonas spp. from hospital effluent impacted waterbodies: antagonistic potential by plant-based antimicrobials.Molecular biology reports · 2025Article
- Chemical profiling and mechanistic insights into the antibacterial efficacy of Melaleuca cajuputi leaf extract.BMC complementary medicine and therapies · 2025Article
- Antibacterial Activity ofJournal of microbiology and biotechnology · 2025Article
- Pioneering study of Egyptian Neem and Jojoba extracts with molecular docking combat hospital multidrug resistant bacteria.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- QSAR, Antimicrobial, and Antiproliferative Study of (ACS omega · 2025Article
- Assessment of the Anti-Foods (Basel, Switzerland) · 2025Article
- Investigating the Therapeutic Property of Galium verum L. (GV) for MSG induced Audiogenic Epilepsy (AEs) and Neuroprotection throughCentral nervous system agents in medicinal chemistry · 2025Article
- Metabolic profiling and antimicrobial activity ofFrontiers in pharmacology · 2025Article
- 2,4-Di-tert-butylphenol from Endophytic FungiFrontiers in microbiology · 2025Article
- Antifungal, Antioxidant Activity, and GC-MS Profiling of Diaporthe amygdali GWS39: A First Report Endophyte from Geranium wallichianum.Current microbiology · 2024Article
- Article
- The antioxidant and antimicrobial activity of ethanolic extract in roots, stems, and leaves of three commercial Cymbopogon species.BMC complementary medicine and therapies · 2024Article
- Insights into the potential dual-antibacterial mechanism of Kelisha capsule on Escherichia coli.BMC complementary medicine and therapies · 2024Article
- Article
- The geranium genus: A comprehensive study on ethnomedicinal uses, phytochemical compounds, and pharmacological importance.Saudi journal of biological sciences · 2024Review
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
Geranium wallichianum D. Don ex Sweet is a well-known medicinal plant in Kashmir Himalya. The evidence for its modern medicinal applications remains majorly unexplored. The present study was undertaken to elucidate the detailed antimicrobial promises of different crude extracts (methanolic, ethanolic, petroleum ether, and ethyl acetate) of G. wallichainum against common human bacterial and fungal pathogens in order to scientifically validate its traditional use. The LC-MS analysis of G. wallichainum yielded 141 bioactive compounds with the vast majority of them having therapeutic applications. Determination of minimum inhibitory concentrations (MICs) by broth microdilution method of G. wallichainum was tested against bacterial and fungal pathogens with MICs ranging from 0.39 to 400 µg/mL. Furthermore, virtual ligands screening yielded elatine, kaempferol, and germacrene-A as medicinally most active constituents and the potential inhibitors of penicillin-binding protein (PBP), dihydropteroate synthase (DHPS), elongation factor-Tu (Eu-Tu), ABC transporter, 1,3 beta glycan, and beta-tubulin. The root mean square deviation (RMSD) graphs obtained through the molecular dynamic simulations (MDS) indicated the true bonding interactions which were further validated using root mean square fluctuation (RMSF) graphs which provided a better understanding of the amino acids present in the proteins responsible for the molecular motions and fluctuations. The effective binding of elatine, kaempferol, and germacrene-A with these proteins provides ground for further research to understand the underlying mechanism that ceases the growth of these microbes.
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