ArticleNature communications2022
A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells.
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Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49citing papers in PubMed
10.3field-weighted citation impact, top 1% of its field
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Who cites it
49 citing papers in PubMed, 88 citations in OpenAlex.
- Cortistatin antagonizes Piezo1-STING axis and facilitates mitochondrial homeostasis of keratinocytes by attenuating AGEs accumulation in diabetic ulcers.Cell death and differentiation · 2026Article
- Article
- PIEZO Channels in Metabolism and Metabolic Diseases: Research Advances and Therapeutic Strategies.Current obesity reports · 2026Review
- Impact of Therapeutic Ultrasound on Metabolic Hormone Release From Thyroid Gland.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026Article
- Piezo ion channels in the digestive system: Mechanotransduction pathways and therapeutic targeting strategies.Genes & diseases · 2026Review
- The Potential Target Value of ADP-Ribosylation Factor 6 in Insulin Secretion Regulation and the Treatment of Metabolic Disorders.Metabolites · 2026Review
- Systematic Expression and Localization Profiling of Piezo2 in Rodent Pancreatic Islets.Nutrients · 2026Article
- Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- PIEZO1 mediates orthodontic tension force-induced alveolar bone remodeling via the Ca²⁺/YAP-TAZ pathway in periodontal ligament stem cells.Journal of translational medicine · 2026Article
- The Emerging Role of Mechanobiology in Connecting Metabolic and Cardiovascular Diseases: From Fundamentals to Future Therapies.Biomedicines · 2026Review
- Mechanostimulation of neuroendocrine cells and their clinical relevance.Molecular and cellular biochemistry · 2026Review
- i-Motif, not G-quadruplex, stability regulates insulin expression.Nucleic acids research · 2026Article
- Microbubble-enhanced ultrasound stimulation of β-cells improves insulin release and glycemic control in mice.Journal of nanobiotechnology · 2025Article
- SERCA2 regulates Piezo1 channel activation and contributes to the cardiac function and baroreflex in mice.Acta pharmacologica Sinica · 2025Article
- Hepatocyte Piezo1 regulates glycogen metabolism via the FGF21-STAT3 pathway.Cellular and molecular life sciences : CMLS · 2025Article
- Pancreatic Cancer and Diabetes: Insights, Hypotheses, and Next Steps.International journal of molecular sciences · 2025Review
- PIEZO1: a mechanosensitive ion channel in the pathogenesis and pharmacotherapy of diabetic neuropathy.Molecular biology reports · 2025Review
- Mechanosensitive Channels Mediate Pancreatic β Cells Reactive Oxygen Species Formation and Downregulation of Essential Genes During Therapeutic Ultrasound Treatment.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025Article
- The mechanotransducer Piezo1 coordinates metabolism and inflammation to promote skin growth.Nature communications · 2025Article
- LRRC8 channel complexes counterbalance KATP channels to mediate swell-secretion coupling in mouse pancreatic β cells.JCI insight · 2025Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 3 countries.
Yingying Ye *Lund University Diabetes Centre, Department of Clinical Sciences Malmö, Unit of Islet Pathophysiology, Lund University, 20502, Malmö, Sweden.ORCID 0000-0003-3648-7167
Mohammad Barghouth *Lund University Diabetes Centre, Department of Clinical Sciences Malmö, Unit of Islet Pathophysiology, Lund University, 20502, Malmö, Sweden.
Haiqiang Dou *Metabolic Research Unit, Institute of Neuroscience and Physiology, Department of Physiology, University of Göteborg, 405 30, Göteborg, Sweden.ORCID 0000-0002-1551-4114
Cheng LuanLund University Diabetes Centre, Department of Clinical Sciences Malmö, Unit of Islet Pathophysiology, Lund University, 20502, Malmö, Sweden.ORCID 0000-0003-4466-0687
Yongzhi WangSection for Surgery, Department of Clinical Sciences Malmö, Lund University, 20502, Malmö, Sweden.ORCID 0000-0002-0999-5126
Alexandros KaragiannopoulosLund University Diabetes Centre, Department of Clinical Sciences Malmö, Unit of Islet Cell Exocytosis, Lund University, 20502, Malmö, Sweden.ORCID 0000-0001-8458-1065
Xiaoping JiangLund University Diabetes Centre, Department of Clinical Sciences Malmö, Unit of Islet Pathophysiology, Lund University, 20502, Malmö, Sweden.
Ulrika KrusLund University Diabetes Centre, Department of Clinical Sciences Malmö, Unit of Islet Pathophysiology, Lund University, 20502, Malmö, Sweden.
Malin FexLund University Diabetes Centre, Department of Clinical Sciences in Malmö, Unit of Molecular Metabolism, Malmö University Hospital, Lund University, 20502, Malmö, Sweden.
Quan ZhangOxford Centre for Diabetes, Endocrinology, and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 7LE, UK.ORCID 0000-0002-3626-4855
Lena EliassonLund University Diabetes Centre, Department of Clinical Sciences Malmö, Unit of Islet Cell Exocytosis, Lund University, 20502, Malmö, Sweden.ORCID 0000-0002-6467-5029
Patrik RorsmanMetabolic Research Unit, Institute of Neuroscience and Physiology, Department of Physiology, University of Göteborg, 405 30, Göteborg, Sweden.ORCID 0000-0001-7578-0767
Enming ZhangLund University Diabetes Centre, Department of Clinical Sciences Malmö, Unit of Islet Pathophysiology, Lund University, 20502, Malmö, Sweden. enming.zhang@med.lu.se.ORCID 0000-0002-0401-4608
Erik RenströmLund University Diabetes Centre, Department of Clinical Sciences Malmö, Unit of Islet Pathophysiology, Lund University, 20502, Malmö, Sweden. erik.renstrom@med.lu.se.ORCID 0000-0002-4065-4485
Lund University · SEMalmö University · SEUniversity of Oxford · GBSouthwest University · CNUniversity of Gothenburg · SE
Funding
Medical Research Council MR/T002107/1Medical Research Council MR/V011979/1
Abstract
Glucose-induced insulin secretion depends on β-cell electrical activity. Inhibition of ATP-regulated potassium (K
Indexed as
Diabetes Mellitus, Type 2GlucoseAdenosine TriphosphateAnimalsCalciumHumansInsulinInsulin SecretionIon ChannelsMechanotransduction, CellularMiceAdenosine TriphosphateCalciumGlucoseInsulinIon ChannelsPIEZO1 protein, humanPiezo1 protein, mouse
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.