Evidence map›Paper›PMID 35868499›Full record

ReviewCritical reviews in oncology/hematology2022

The impact of local therapies for breast cancer on shoulder muscle health and function.

Joshua M Leonardis, Tea Lulic-Kuryllo, David B Lipps

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Critical reviews in oncology/hematology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 29 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Association Between Danish Guideline Treatments for Breast Cancer and Physiotherapy-Relevant Late Effects: A Nationwide Cohort Study.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026
    Article
  4. Article
  5. Article
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  7. Article
  8. Breast cancer related lymphedema and shoulder mobility following radiotherapy.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026
    Article
  9. Article
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  11. Article
  12. Article
  13. Article
  14. Nurse-led support impact via a mobile app for breast cancer patients after surgery: a quasi-experimental study (step 2).Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  15. Postmastectomy Functional Impairments.Current oncology reports · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Joshua M LeonardisSchool of Kinesiology, University of Michigan, Ann Arbor, MI, USA.
Tea Lulic-KurylloSchool of Kinesiology, University of Michigan, Ann Arbor, MI, USA.
David B LippsSchool of Kinesiology, University of Michigan, Ann Arbor, MI, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. Electronic address: dlipps@umich.edu.
University of Michigan–Ann Arbor · US

Funding

Improving the assessment and diagnosis of shoulder morbidity following mastectomy with breast reconstructionR03HD097704 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIPPS, DAVID B · 2019 to 2020
$298k
NICHD NIH HHS R03 HD097704
6 · The paper itself

Abstract

Advances in breast cancer treatment have improved patient survival but have also created complications, such as shoulder morbidity, impacting the patient's quality of life. Local therapies for breast cancer influence shoulder muscle health through changes to the muscular microenvironment, macroscopic muscle morphology, and neuromuscular function. Our findings suggest both surgery and radiation therapy compromise the healthy functioning of shoulder musculature. Mastectomy and post-mastectomy breast reconstruction directly affect shoulder function through muscle morphology and neuromuscular function alterations. Radiation therapy damages satellite cells and myocytes, causing cell death both during treatment and years after recovery. This damage creates an environment limited in its ability to prevent atrophy. However, research to date is limited to a small number of analyses with small experimental populations and a lack of control for covariates. Future research to uncover the pathophysiological mechanisms underlying shoulder morbidity after breast cancer treatment must integrate measures of shoulder muscle health and shoulder function.

Indexed as

Breast NeoplasmsShoulder JointFemaleHumansMastectomyMuscle, SkeletalQuality of LifeShoulderTumor MicroenvironmentBreast reconstructionJoint functionMuscle functionNeuromuscular systemRadiation therapyShoulder morbidity

Identifiers

PMID35868499
PMCPMC9706536
OpenAlexW4286251269

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.