Evidence map›Paper›PMID 35868485›Full record

ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2023

Cingulate-Prefrontal Connectivity During Dynamic Cognitive Control Mediates Association Between p Factor and Adaptive Functioning in a Transdiagnostic Pediatric Sample.

Adam Kaminski, Xiaozhen You, Kathryn Flaharty, Charlotte Jeppsen, Sufang Li, Junaid S Merchant, Madison M Berl, Lauren Kenworthy, Chandan J Vaidya

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In one paragraph

Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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  5. Self- vs. External-Regulation Behavior ScaleFrontiers in psychology · 2022
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Adam KaminskiDepartment of Psychology, Georgetown University, Washington, D.C.. Electronic address: ak1821@georgetown.edu.
Xiaozhen YouChildren's Research Institute, Children's National Medical Center, Washington, D.C.
Kathryn FlahartyDepartment of Psychology, Georgetown University, Washington, D.C.
Charlotte JeppsenChildren's Research Institute, Children's National Medical Center, Washington, D.C.
Sufang LiDepartment of Psychology, Georgetown University, Washington, D.C.
Junaid S MerchantDepartment of Psychology, Georgetown University, Washington, D.C.
Madison M BerlChildren's Research Institute, Children's National Medical Center, Washington, D.C.
Lauren KenworthyChildren's Research Institute, Children's National Medical Center, Washington, D.C.
Chandan J VaidyaDepartment of Psychology, Georgetown University, Washington, D.C.; Children's Research Institute, Children's National Medical Center, Washington, D.C.. Electronic address: cjv2@georgetown.edu.

Funding

Multimodal Developmental Neurogenetics of Females with ASDR01MH100028 · NIMH · YALE UNIVERSITY · PI Allison Elizabeth Jack, LAUREN KENWORTHY · 2012 to 2026
$37.8M
Neurobehavioral Evaluation CoreP50HD105328 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI WILLIAM Davis GAILLARD · 2021 to 2026
$9.3M
Characterization of executive function dimensions across pediatric psychiatric disordersR01MH110512 · NIMH · GEORGETOWN UNIVERSITY · PI KENWORTHY, LAUREN, VAIDYA, CHANDAN J · 2016 to 2021
$2.2M
NICHD NIH HHS P50 HD105328NIMH NIH HHS R01 MH100028NIMH NIH HHS R01 MH110512
6 · The paper itself

Abstract

backgroundCovariation among psychiatric symptoms is being actively pursued for transdiagnostic dimensions of psychopathology with predictive utility. A superordinate dimension, the p factor, reflects overall psychopathology burden and has support from genetic and neuroimaging correlates. However, the neurocognitive correlates that link an elevated p factor to maladaptive outcomes are unknown. We tested the mediating potential of dynamic adjustments in cognitive control rooted in functional connections anchored by the dorsal anterior cingulate cortex (dACC) in a transdiagnostic pediatric sample.

methodsA multiple mediation model tested the association between the p factor (derived by principal component analysis of Child Behavior Checklist syndrome scales) and outcome measured with the Vineland Adaptive Behavior Scale-II in 89 children ages 8 to 13 years (23 female) with a variety of primary neurodevelopmental diagnoses who underwent functional magnetic resonance imaging during a socioaffective Stroop-like task with eye gaze as distractor. Mediators included functional connectivity of frontoparietal- and salience network-affiliated dACC seeds during conflict adaptation.

resultsHigher p factor scores were related to worse adaptive functioning. This effect was partially mediated by conflict adaptation-dependent functional connectivity between the frontoparietal network-affiliated dACC seed and the right dorsolateral prefrontal cortex. Post hoc follow-up indicated that the p factor was related to all Vineland Adaptive Behaviors Scale-II domains; the association was strongest for socialization followed by daily living skills and then communication. Mediation results remained significant for socialization only.

conclusionsHigher psychopathology burden was associated with worse adaptive functioning in early adolescence. This association was mediated by weaker dACC-dorsolateral prefrontal cortex functional connectivity underlying modulation of cognitive control in response to contextual contingencies. Our results contribute to the identification of transdiagnostic and developmentally relevant neurocognitive endophenotypes of psychopathology.

Indexed as

Gyrus CinguliMental DisordersAdolescentChildCognitionFemaleHumansMagnetic Resonance ImagingNeuroimagingAdaptive functioningAnterior cingulateConflict adaptationp factorSeed-to-voxel gPPITransdiagnostic

Identifiers

PMID35868485
PMCPMC10152206

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.