Evidence map›Paper›PMID 35868310›Full record

ArticleCell metabolism2022

T-bet

Thomas Hägglöf, Carlo Vanz, Abigail Kumagai, Elizabeth Dudley, Vanessa Ortega, McKenzie Siller, Raksha Parthasarathy, Josh Keegan, Abigail Koenigs, Travis Shute and 1 more

Open access · greenAbstract read
In one paragraph

Article in Cell metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
6.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
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  14. Inflammation and Resolution in Obesity-Related Cardiovascular Disease.International journal of molecular sciences · 2026
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Thomas HägglöfDepartment of Microbiology, Immunology & Molecular Genetics, UT Health, San Antonio, TX 78229, USA.
Carlo VanzDepartment of Microbiology, Immunology & Molecular Genetics, UT Health, San Antonio, TX 78229, USA.
Abigail KumagaiDepartment of Microbiology, Immunology & Molecular Genetics, UT Health, San Antonio, TX 78229, USA.
Elizabeth DudleyDepartment of Microbiology, Immunology & Molecular Genetics, UT Health, San Antonio, TX 78229, USA.
Vanessa OrtegaDepartment of Microbiology, Immunology & Molecular Genetics, UT Health, San Antonio, TX 78229, USA.
McKenzie SillerDepartment of Microbiology, Immunology & Molecular Genetics, UT Health, San Antonio, TX 78229, USA.
Raksha ParthasarathyDepartment of Microbiology, Immunology & Molecular Genetics, UT Health, San Antonio, TX 78229, USA.
Josh KeeganDepartment of Microbiology, Immunology & Molecular Genetics, UT Health, San Antonio, TX 78229, USA.
Abigail KoenigsDepartment of Microbiology, Immunology & Molecular Genetics, UT Health, San Antonio, TX 78229, USA.
Travis ShuteDepartment of Microbiology, Immunology & Molecular Genetics, UT Health, San Antonio, TX 78229, USA.
Elizabeth A LeadbetterDepartment of Microbiology, Immunology & Molecular Genetics, UT Health, San Antonio, TX 78229, USA. Electronic address: leadbetter@uthscsa.edu.
The University of Texas Health Science Center at San Antonio · US

Funding

Adiponectin signaling and macrophage functionR01DK134637 · NIDDK · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lily Q Dong, ELIZABETH Ann LEADBETTER · 2023 to 2026
$2.1M
Innate modulation of autoimmune, regulatory, and effector B cells in adipose tissueR01AI132798 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LEADBETTER, ELIZABETH ANN · 2018 to 2022
$1.9M
NIAID NIH HHS R01 AI132798NIDDK NIH HHS R01 DK134637
6 · The paper itself

Abstract

Obesity is accompanied by inflammation in adipose tissue, impaired glucose tolerance, and changes in adipose leukocyte populations. These studies of adipose tissue from humans and mice revealed that increased frequencies of T-bet

Indexed as

Diabetes Mellitus, Type 2Insulin ResistanceMetabolic DiseasesAdipose TissueAnimalsDiet, High-FatHumansImmunoglobulin GInflammationMiceMice, Inbred C57BLMice, KnockoutObesityImmunoglobulin Gadipose tissueB cellsCD11c(+) T-bet(+) B cellsglucose intoleranceIgG2cinflammationiNKT cellsmetabolic disorderobesitytype 2 diabetes

Identifiers

PMID35868310
PMCPMC9357106
OpenAlexW4286515932

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.