Evidence map›Paper›PMID 35867841›Full record

ReviewThe British journal of radiology2022

Current status and future developments in predicting outcomes in radiation oncology.

Dipesh Niraula, Sunan Cui, Julia Pakela, Lise Wei, Yi Luo, Randall K Ten Haken, Issam El Naqa

Abstract readReview
In one paragraph

Review in The British journal of radiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Uncertainties in outcome modelling in radiation oncology.Physics and imaging in radiation oncology · 2025
    Review
  6. [Prognosis-guided optimization of intensity-modulated radiation therapy plans for lung cancer].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025
    Article
  7. Article
  8. Review
  9. Improved outcome models with denoising diffusion.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2024
    Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dipesh NiraulaDepartment of Machine Learning, H Lee Moffitt Cancer Center and Research Institute, Tampa, USA.ORCID 0000-0002-2245-8536
Sunan CuiDepartment of Radiation Oncology, Stanford Medicine, Stanford University, Stanford, USA.
Julia PakelaDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA.
Lise WeiDepartment of Radiation Oncology, University of Michigan, Ann Arbor, USA.
Yi LuoDepartment of Machine Learning, H Lee Moffitt Cancer Center and Research Institute, Tampa, USA.
Randall K Ten HakenDepartment of Radiation Oncology, University of Michigan, Ann Arbor, USA.
Issam El NaqaDepartment of Machine Learning, H Lee Moffitt Cancer Center and Research Institute, Tampa, USA.

Funding

Optimal Decision Making in Radiotherapy Using Panomics AnalyticsR01CA233487 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI EL NAQA, ISSAM M. · 2019 to 2023
$2.4M
NCI NIH HHS R01 CA233487
6 · The paper itself

Abstract

Advancements in data-driven technologies and the inclusion of information-rich multiomics features have significantly improved the performance of outcomes modeling in radiation oncology. For this current trend to be sustainable, challenges related to robust data modeling such as small sample size, low size to feature ratio, noisy data, as well as issues related to algorithmic modeling such as complexity, uncertainty, and interpretability, need to be mitigated if not resolved. Emerging computational technologies and new paradigms such as federated learning, human-in-the-loop, quantum computing, and novel interpretability methods show great potential in overcoming these challenges and bridging the gap towards precision outcome modeling in radiotherapy. Examples of these promising technologies will be presented and their potential role in improving outcome modeling will be discussed.

Indexed as

Radiation OncologyComputing MethodologiesHumansMachine LearningQuantum Theory

Identifiers

PMID35867841
PMCPMC9793488

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.