ArticleScience immunology2022
Human T-bet governs the generation of a distinct subset of CD11c
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Article in Science immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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52citing papers in PubMed
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52 citing papers in PubMed, 77 citations in OpenAlex.
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- TCR γδ cell-specific STAT5 gain of function induces a druggable chronic human immune dysregulation.Journal of human immunity · 2026Article
- The Vaccine Candidates Against Major Fish Pathogens (Life (Basel, Switzerland) · 2026Article
- The Developmental and Functional Implications of Age-Associated B Cells (ABCs) Across Tissue Microenvironments.Immunological reviews · 2026Review
- Human inherited RORγT deficiency encompasses genetic heterogeneity, T cell deficiency, and clinical homogeneity.medRxiv : the preprint server for health sciences · 2026Article
- Human CD21Journal of human immunity · 2026Review
- Chronic graft-versus-host disease.Nature reviews. Disease primers · 2026Review
- IFN-gene signatures in B cells following influenza A and B virus infection and influenza vaccination.EMBO molecular medicine · 2026Article
- Robust effector memory features of human T-betiScience · 2026Article
- Somatic deficiency of the human E3 ubiquitin ligase CBL in leukocytes impairs B cell but not T cell development and function.Nature immunology · 2026Article
- The multilayered identity of B cell memory.Cellular & molecular immunology · 2026Review
- CD21Frontiers in aging · 2026Article
- Significance of RGS13 expression in lupus B cells.PloS one · 2026Article
- Could belimumab be a new weapon in autoimmune complicated CVID?Frontiers in immunology · 2026Article
- Article
- Progression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation.Science translational medicine · 2025Article
- The Immunodeficiency Profile of Lymphocytes in the Patient with Moesin Gene Mutation During Different Infection.Journal of clinical immunology · 2025Article
- Single-cell atlas reveals heterogeneous response to FcRn blockade in anti-AChR antibody-positive generalised myasthenia gravis.Clinical and translational medicine · 2025Article
- Early multiple sclerosis activity associated with TBX21+CD21loCXCR3+ B cell expansion resembling EBV-induced phenotypes.JCI insight · 2025Article
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Authors and funding
36 authors at 15 institutions in 7 countries.
Rui YangSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA.ORCID 0000-0003-4427-2158
Danielle T AveryGarvan Institute of Medical Research, Darlinghurst, NSW 2010 Australia.ORCID 0000-0002-9156-0489
Katherine J L JacksonGarvan Institute of Medical Research, Darlinghurst, NSW 2010 Australia.ORCID 0000-0002-9952-7069
Masato OgishiSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA.ORCID 0000-0003-2421-7389
Ibtihal BenhsaienLaboratory of Clinical Immunology, Inflammation, and Allergy, Faculty of Medicine and Pharmacy of Casablanca, King Hassan II University, 20460 Casablanca, Morocco.ORCID 0000-0001-5727-9629
Likun DuDepartment of Biosciences and Nutrition, Karolinska Institutet, 14183 Huddinge, Sweden.ORCID 0000-0002-8448-2187
Xiaofei YeDepartment of Biosciences and Nutrition, Karolinska Institutet, 14183 Huddinge, Sweden.ORCID 0000-0002-7678-1152
Jing HanSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA.ORCID 0000-0003-2307-438X
Jérémie RosainLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, Necker Hospital for Sick Children, 75015 Paris, France.ORCID 0000-0002-2822-161X
Jessica N PeelSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA.
Marie-Alexandra AlyanakianImmunology Laboratory, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris (AP-HP), 75015 Paris, France.
Bénédicte NevenDepartment of Pediatric Immunology, Hematology, and Rheumatology, Necker Hospital for Sick Children, AP-HP, Paris, France.
Sarah WinterParis Cité University, Imagine Institute, 75015 Paris, France.ORCID 0000-0001-7985-3986
Anne PuelSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA.ORCID 0000-0003-2603-0323
Bertrand BoissonSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA.ORCID 0000-0001-5240-3555
Kathryn J PayneGarvan Institute of Medical Research, Darlinghurst, NSW 2010 Australia.ORCID 0000-0003-3311-5210
Melanie WongChildren's Hospital at Westmead, Westmead, NSW, Australia.
Amanda J RussellGarvan Institute of Medical Research, Darlinghurst, NSW 2010 Australia.ORCID 0000-0001-7148-1081
Yoko MizoguchiDepartment of Pediatrics, Hiroshima University, Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.
Satoshi OkadaDepartment of Pediatrics, Hiroshima University, Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.ORCID 0000-0002-4622-5657
Gulbu UzelLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Christopher C GoodnowGarvan Institute of Medical Research, Darlinghurst, NSW 2010 Australia.ORCID 0000-0001-5296-6155
Sylvain LatourParis Cité University, Imagine Institute, 75015 Paris, France.ORCID 0000-0001-8238-4391
Jalila El BakkouriLaboratory of Clinical Immunology, Inflammation, and Allergy, Faculty of Medicine and Pharmacy of Casablanca, King Hassan II University, 20460 Casablanca, Morocco.ORCID 0000-0003-2303-3369
Aziz BousfihaLaboratory of Clinical Immunology, Inflammation, and Allergy, Faculty of Medicine and Pharmacy of Casablanca, King Hassan II University, 20460 Casablanca, Morocco.ORCID 0000-0002-5011-9873
Kahn PreeceJohn Hunter Children's Hospital, Newcastle, NSW, Australia.ORCID 0000-0002-7326-6585
Paul E GraySchool of Women's and Children's Health, UNSW Sydney, Sydney, NSW, Australia.
Baerbel KellerDepartment of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-1491-6971
Klaus WarnatzDepartment of Rheumatology and Clinical Immunology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-1172-865X
Stéphanie Boisson-DupuisSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA.ORCID 0000-0002-7115-116X
Laurent AbelSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA.ORCID 0000-0001-7016-6493
Qiang Pan-HammarströmDepartment of Biosciences and Nutrition, Karolinska Institutet, 14183 Huddinge, Sweden.ORCID 0000-0003-1990-8804
Jacinta BustamanteSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA.ORCID 0000-0002-3439-2482
Cindy S MaGarvan Institute of Medical Research, Darlinghurst, NSW 2010 Australia.ORCID 0000-0001-5387-8413
Jean-Laurent CasanovaSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, Rockefeller University, New York, NY 10065, USA.ORCID 0000-0002-7782-4169
Stuart G TangyeGarvan Institute of Medical Research, Darlinghurst, NSW 2010 Australia.ORCID 0000-0002-5360-5180
Inserm · FRGarvan Institute of Medical Research · AUKarolinska Institutet · SERockefeller University · USUniversity of Hassan II Casablanca · MAHiroshima University · JPUniversity of Freiburg · DEAssistance Publique – Hôpitaux de Paris · FRCornell University · USHospital for Sick Children Pediatric Center · USHoward Hughes Medical Institute · USJohn Hunter Children's Hospital · AUNational Institutes of Health · USThe University of Sydney · AUUNSW Sydney · AU
Funding
Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6MGenome-Wide Dissection of Mendelian Susceptibility to Mycobacterial DiseaseR37AI095983 · NIAID · ROCKEFELLER UNIVERSITY · PI CASANOVA, JEAN-LAURENT · 2011 to 2020
$4.6MHoward Hughes Medical InstituteNCATS NIH HHS UL1 TR001866NIAID NIH HHS R37 AI095983
Abstract
High-level expression of the transcription factor T-bet characterizes a phenotypically distinct murine B cell population known as "age-associated B cells" (ABCs). T-bet-deficient mice have reduced ABCs and impaired humoral immunity. We describe a patient with inherited T-bet deficiency and largely normal humoral immunity including intact somatic hypermutation, affinity maturation and memory B cell formation in vivo, and B cell differentiation into Ig-producing plasmablasts in vitro. Nevertheless, the patient exhibited skewed class switching to IgG1, IgG4, and IgE, along with reduced IgG2, both in vivo and in vitro. Moreover, T-bet was required for the in vivo and in vitro development of a distinct subset of human B cells characterized by reduced expression of CD21 and the concomitantly high expression of CD19, CD20, CD11c, FCRL5, and T-bet, a phenotype that shares many features with murine ABCs. Mechanistically, human T-bet governed CD21
Indexed as
B-LymphocytesPlasma CellsAdaptor Proteins, Signal TransducingAnimalsCD11c AntigenGene Expression RegulationHumansImmunoglobulin GLipoproteinsLymphocyte ActivationMiceAdaptor Proteins, Signal TransducingCD11c AntigenDapp1 protein, mouseImmunoglobulin GLipoproteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.