ArticleScience immunology2022
TREM2 macrophages induced by human lipids drive inflammation in acne lesions.
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Article in Science immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
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88citing papers in PubMed
11.5field-weighted citation impact, top 1% of its field
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Who cites it
88 citing papers in PubMed, 139 citations in OpenAlex.
- Acne: epidemiology, risk factors, pathogenesis, management and cutting-edge research.Signal transduction and targeted therapy · 2026Review
- Immune dysregulation in the prostates of C57BL/6The Journal of pathology · 2026Article
- Single-cell RNA sequencing reveals the interaction of TREM2Immunologic research · 2026Article
- Chessboard Microneedle Array for Inflammation Regulation via Spatiotemporally Controlled Drug Delivery.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Lipid metabolism, microglia, and stroke.Neural regeneration research · 2026Article
- A Global Delphi Consensus on Acne and the Microbiome: Integrating International Expertise for Innovative Prevention and Therapeutic Strategies.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Macrophages with ITIH4 overexpression attenuate inflammatory responses and regulate intestinal epithelial cells.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Fluorescence-Guided Spatial Mapping of p21-Expressing Senescent Cells in Aged Liver at Single-Cell Resolution.Biomolecules · 2026Article
- Hidden immune memory niches in inflammatory skin diseases.bioRxiv : the preprint server for biology · 2026Article
- Integrating Dermocosmetics Into Acne Care in Latin America.Journal of cosmetic dermatology · 2026Review
- Spatial transcriptomics identifies differentiation, lipid metabolism, and retinoid pathway alterations in acne vulgaris.JCI insight · 2026Article
- Spatial transcriptomics reveals immune-stromal crosstalk within the synovium of patients with juvenile idiopathic arthritis.JCI insight · 2026Article
- CircRNA Profiling Identifies hsa_circRNA_003201 Associated with a Predicted NLRX1-Related Regulatory Network in an Acne-Associated Inflammatory Sebocyte Model.Journal of inflammation research · 2026Article
- Targeting macrophages in liver fibrosis.Frontiers in immunology · 2026Review
- Targeting macrophage polarization: mechanisms and potential of mesenchymal stromal/stem cells therapy in acne treatment- a narrative review.Frontiers in immunology · 2026Review
- Immune Activation and Glycolytic Responses to Cutibacterium acnes Cell Wall Polysaccharides.The Journal of investigative dermatology · 2025Article
- Bullous Pemphigoid Develops Independently of DAP12.Biomolecules · 2025Article
- A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated macrophages in lupus nephritis.The Journal of experimental medicine · 2025Article
- Deciphering metabolic reprogramming of immune cells within the tumor microenvironment.Journal of translational medicine · 2025Article
- A single-cell and spatial genomics atlas of human skin fibroblasts reveals shared disease-related fibroblast subtypes across tissues.Nature immunology · 2025Article
28 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 7 institutions in 1 country.
Tran H DoMolecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-6317-9202
Feiyang MaMolecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-6260-0787
Priscila R AndradeDivision of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles,, Los Angeles, CA 90095, USA.
Rosane TelesDivision of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles,, Los Angeles, CA 90095, USA.ORCID 0000-0003-2908-3244
Bruno J de Andrade SilvaDivision of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles,, Los Angeles, CA 90095, USA.ORCID 0000-0002-0362-1860
Chanyue HuInstitute for Quantitative and Computational Biosciences-The Collaboratory, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-2730-9684
Alejandro EspinozaInstitute for Quantitative and Computational Biosciences-The Collaboratory, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-2958-4209
Jer-En HsuDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Chun-Seok ChoDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-9589-5745
Myungjin KimDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Jingyue XiDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA.
Xianying XingDepartment of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-4227-6868
Olesya PlazyoDepartment of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-6859-7590
Lam C TsoiDepartment of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-1627-5722
Carol ChengDivision of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles,, Los Angeles, CA 90095, USA.
Jenny KimDivision of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles,, Los Angeles, CA 90095, USA.
Bryan D BrysonDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0003-1716-6712
Alan M O'NeillDepartment of Dermatology, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-5892-6477
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-5222-4987
Johann E GudjonssonDepartment of Dermatology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-0080-0812
Eynav KlechevskyDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-6121-1571
Jun Hee LeeDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.ORCID 0000-0002-2200-6011
Richard L GalloDepartment of Dermatology, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-1401-7861
Barry R BloomDepartment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID 0000-0002-2068-7263
Matteo PellegriniInstitute for Quantitative and Computational Biosciences-The Collaboratory, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-9355-9564
Robert L ModlinDivision of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles,, Los Angeles, CA 90095, USA.ORCID 0000-0003-4720-031X
University of Michigan · USUniversity of California, Los Angeles · USQB3 · USUniversity of California San Diego · USWashington University in St. Louis · USHarvard University · USMassachusetts Institute of Technology · US
Funding
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2MUCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9MMolecular Analysis of the Host Immune Response in LeprosyR01AI022553 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROBERT L MODLIN · 1989 to 2026
$15.7MResearch Training in BiogerontologyT32AG000114 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCOTT PLETCHER · 1985 to 2026
$12.4MTCR GAMMA/DELTA LYMPHOCYTES IN HUMAN SKIN LESIONSR01AR040312 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MODLIN, ROBERT L · 1990 to 2025
$10.4MMicrobiology and Metagenomics CoreP50AR080594 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ROBERT L MODLIN · 2022 to 2026
$9.2MUniversity of Michigan Skin Biology and Diseases Resource-based CenterP30AR075043 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Johann Eli Gudjonsson · 2019 to 2026
$6.6MThe skin microbiome in acneR01AR074302 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GALLO, RICHARD L, MODLIN, ROBERT L · 2018 to 2022
$2.6MIL-26 in host defense against infection by intracellular bacteria in skinR01AR073252 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MODLIN, ROBERT L · 2019 to 2023
$2.1MThe Role of CD5 in Tumor ImmunityR01CA245277 · NCI · WASHINGTON UNIVERSITY · PI KLECHEVSKY, EYNAV YAFIT · 2020 to 2024
$1.8MHarnessing Human Dendritic Cell Subsets in Skin for the Design of Novel ImmunotherapiesR01AR075959 · NIAMS · WASHINGTON UNIVERSITY · PI KLECHEVSKY, EYNAV YAFIT · 2019 to 2023
$1.7MDermatology Scientist Training ProgramT32AR071307 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MODLIN, ROBERT L · 2017 to 2021
$1.1MNCI NIH HHS R01 CA245277NCI NIH HHS UG3 CA268091NIAID NIH HHS R01 AI022553NIAMS NIH HHS P30 AR075043NIAMS NIH HHS P50 AR080594NIAMS NIH HHS R01 AR040312NIAMS NIH HHS R01 AR073252NIAMS NIH HHS R01 AR074302NIAMS NIH HHS R01 AR075959NIAMS NIH HHS T32 AR071307NIA NIH HHS K01 AG061236NIA NIH HHS T32 AG000114NIDDK NIH HHS P30 DK056341NIGMS NIH HHS T32 GM008042
Abstract
Acne affects 1 in 10 people globally, often resulting in disfigurement. The disease involves excess production of lipids, particularly squalene, increased growth of
Indexed as
Acne VulgarisSqualeneHumansInflammationLipidsMacrophagesMembrane GlycoproteinsReceptors, ImmunologicLipidsMembrane GlycoproteinsReceptors, ImmunologicSqualeneTREM2 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.