Evidence map›Paper›PMID 35867659›Full record

SynthesisPLoS neglected tropical diseases2022

Epidemiology of yellow fever virus in humans, arthropods, and non-human primates in sub-Saharan Africa: A systematic review and meta-analysis.

Martin Gael Oyono, Sebastien Kenmoe, Ngu Njei Abanda, Guy Roussel Takuissu, Jean Thierry Ebogo-Belobo, Raoul Kenfack-Momo, Cyprien Kengne-Nde, Donatien Serge Mbaga, Serges Tchatchouang, Josiane Kenfack-Zanguim and 8 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PLoS neglected tropical diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 3 pooled it
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 29 citations in OpenAlex.

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  14. The making of a dangerous vector: factors shaping the vector competence ofFrontiers in cellular and infection microbiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 1 country.

Martin Gael OyonoCentre for Research on Health and Priority Pathologies, Institute of Medical Research and Medicinal Plants Studies, Yaounde, Cameroon.
Sebastien KenmoeDepartment of Microbiology and Parasitology, University of Buea, Buea, Cameroon.ORCID 0000-0002-5536-080X
Ngu Njei AbandaVirology Department, Centre Pasteur of Cameroon, Yaounde, Cameroon.
Guy Roussel TakuissuCentre for Food, Food Security and Nutrition Research, Institute of Medical Research and Medicinal Plants Studies, Yaounde, Cameroon.
Jean Thierry Ebogo-BeloboMedical Research Centre, Institute of Medical Research and Medicinal Plants Studies, Yaounde, Cameroon.
Raoul Kenfack-MomoDepartment of Biochemistry, The University of Yaounde I, Yaounde, Cameroon.
Cyprien Kengne-NdeEpidemiological Surveillance, Evaluation and Research Unit, National AIDS Control Committee, Douala, Cameroon.
Donatien Serge MbagaDepartment of Microbiology, The University of Yaounde I, Yaounde, Cameroon.
Serges TchatchouangScientific Direction, Centre Pasteur of Cameroon, Yaounde, Cameroon.
Josiane Kenfack-ZanguimDepartment of Biochemistry, The University of Yaounde I, Yaounde, Cameroon.
Robertine Lontuo FogangDepartment of Animal Biology, University of Dschang, Dschang, Cameroon.
Elisabeth Zeuko'o MenkemDepartment of Biomedical Sciences, University of Buea, Buea, Cameroon.
Juliette Laure Ndzie OndiguiDepartment of Microbiology, The University of Yaounde I, Yaounde, Cameroon.
Ginette Irma Kame-NgasseMedical Research Centre, Institute of Medical Research and Medicinal Plants Studies, Yaounde, Cameroon.
Jeannette Nina Magoudjou-PekamDepartment of Biochemistry, The University of Yaounde I, Yaounde, Cameroon.
Arnol Bowo-NgandjiDepartment of Microbiology, The University of Yaounde I, Yaounde, Cameroon.
Seraphine Nkie EsemuDepartment of Microbiology and Parasitology, University of Buea, Buea, Cameroon.
Lucy NdipDepartment of Microbiology and Parasitology, University of Buea, Buea, Cameroon.
Université de Yaoundé I · CMUniversity of Buea · CMMinistry of Scientific Research and Innovation · CMCentre Pasteur du Cameroun · CMUniversité de Dschang · CMUniversity of Douala · CM

Funding

European & Developing Countries Clinical Trials Partnership (EDCTP) TMA2019PF-2705
6 · The paper itself

Abstract

Yellow fever (YF) has re-emerged in the last two decades causing several outbreaks in endemic countries and spreading to new receptive regions. This changing epidemiology of YF creates new challenges for global public health efforts. Yellow fever is caused by the yellow fever virus (YFV) that circulates between humans, the mosquito vector, and non-human primates (NHP). In this systematic review and meta-analysis, we review and analyse data on the case fatality rate (CFR) and prevalence of YFV in humans, and on the prevalence of YFV in arthropods, and NHP in sub-Saharan Africa (SSA). We performed a comprehensive literature search in PubMed, Web of Science, African Journal Online, and African Index Medicus databases. We included studies reporting data on the CFR and/or prevalence of YFV. Extracted data was verified and analysed using the random effect meta-analysis. We conducted subgroup, sensitivity analysis, and publication bias analyses using the random effect meta-analysis while I2 statistic was employed to determine heterogeneity. This review was registered with PROSPERO under the identification CRD42021242444. The final meta-analysis included 55 studies. The overall case fatality rate due to YFV was 31.1% (18.3-45.4) in humans and pooled prevalence of YFV infection was 9.4% (6.9-12.2) in humans. Only five studies in West and East Africa detected the YFV in mosquito species of the genus Aedes and in Anopheles funestus. In NHP, YFV antibodies were found only in members of the Cercopithecidae family. Our analysis provides evidence on the ongoing circulation of the YFV in humans, Aedes mosquitoes and NHP in SSA. These observations highlight the ongoing transmission of the YFV and its potential to cause large outbreaks in SSA. As such, strategies such as those proposed by the WHO's Eliminate Yellow Fever Epidemics (EYE) initiative are urgently needed to control and prevent yellow fever outbreaks in SSA.

Indexed as

AedesArthropodsYellow FeverAfrica South of the SaharaAnimalsHumansPrimatesYellow fever virus

Identifiers

PMID35867659
PMCPMC9307179
OpenAlexW4286587055

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.