Evidence map›Paper›PMID 35867636›Full record

ArticleActa psychiatrica Scandinavica2022

Autism and self-harm: A population-based and discordant sibling study of young individuals.

Isidora Stark, Dheeraj Rai, Michael Lundberg, Iryna Culpin, Selma Idring Nordström, Anna Ohlis, Cecilia Magnusson

Open access · hybridAbstract read
In one paragraph

Article in Acta psychiatrica Scandinavica, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Isidora StarkKarolinska Institutet, Department of Global Public Health, Stockholm, Sweden.ORCID 0000-0001-9349-8415
Dheeraj RaiCentre for Academic Mental Health, Population Health Sciences, Bristol Medical School, Bristol, UK.
Michael LundbergKarolinska Institutet, Department of Global Public Health, Stockholm, Sweden.
Iryna CulpinCentre for Academic Mental Health, Population Health Sciences, Bristol Medical School, Bristol, UK.
Selma Idring NordströmCentre for Psychiatry Research, Department of Clinical Neuroscience, Stockholm, Sweden.
Anna OhlisKarolinska Institutet, Department of Global Public Health, Stockholm, Sweden.ORCID 0000-0001-9046-5773
Cecilia MagnussonKarolinska Institutet, Department of Global Public Health, Stockholm, Sweden.
Karolinska Institutet · SEAt Bristol · GBCentre for Palaeogenetics · SEManchester Metropolitan University · GB

Funding

Department of HealthWellcome TrustWellcome Trust 212664/Z/18/Z
6 · The paper itself

Abstract

objectiveSelf-harm among young autistic individuals is a clinical challenge, and the risk of premature death by suicide is strongly increased in this group. Using the advantage of total-population and family-based data, we investigated whether autism per se is a risk factor for self-harm independently of psychiatric comorbidities and how it differs from self-harm in non-autistic individuals.

methodsWe used The Stockholm Youth Cohort, a total-population register study, including all residents in Stockholm County aged 0-17 years between 2001 and 2011.Study participants were followed from age 10 to 27 for hospital admissions because of self-harm. We used modified Poisson regression to calculate relative risks (RR) using robust standard error to derive 95% confidence intervals (CI).

resultsIn all, 410,732 individuals were included in the cohort (9,070 with a diagnosis of autism). Autistic individuals had a fivefold increased adjusted relative risk of self-harm (RR 5.0 [95% CI 4.4-5.6]). The risk increase was more pronounced for autism without intellectual disability and particularly high for self-cutting 10.2 [7.1-14.7] and more violent methods 8.9 [5.2-15.4]. The association between autism and self-harm was independent of, but clearly exacerbated by comorbid psychiatric conditions. It was of similar magnitude as risks linked to these conditions per se, and not explained by shared familial factors.

conclusionSelf-harm severe enough to present to medical services is as common in autistic youth as in those with depression or ADHD. Potentially more lethal methods are more likely to be used of autistic self-harmers.

Indexed as

Autistic DisorderSelf-Injurious BehaviorSuicideAdolescentHumansRisk FactorsSiblingsautismmental healthpopulation-based cohortself-harmself-injurious behavior

Identifiers

PMID35867636
PMCPMC10286753
OpenAlexW4286587589

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.