Evidence map›Paper›PMID 35867623›Full record

SynthesisMovement disorders : official journal of the Movement Disorder Society2022

Underrepresented Populations in Parkinson's Genetics Research: Current Landscape and Future Directions.

Artur Francisco Schumacher-Schuh, Andrei Bieger, Olaitan Okunoye, Kin Ying Mok, Shen-Yang Lim, Soraya Bardien, Azlina Ahmad-Annuar, Bruno Lopes Santos-Lobato, Matheus Zschornack Strelow, Mohamed Salama and 12 more

Open access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Movement disorders : official journal of the Movement Disorder Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 7 pooled it
20.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 7 syntheses or guidelines pooled it, 82 citations in OpenAlex.

  1. Pooled it
  2. Genetic Landscape of Monogenic Parkinson's Disease in the African Population-A Systematic Review.Movement disorders : official journal of the Movement Disorder Society · 2026
    Pooled it
  3. Pooled it
  4. Classification and Genotype-Phenotype Relationships of GBA1 Variants: MDSGene Systematic Review.Movement disorders : official journal of the Movement Disorder Society · 2025
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Association between C9orf72 G4C2 repeat length and idiopathic Parkinson's disease in a Turkish cohort.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  9. Review
  10. Article
  11. The Global Parkinson's Disease Genetics (GP2) Genome Browser.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  12. Review
  13. Review
  14. Article
  15. Observational
  16. Collaborative Genomics for Dystonia in Central and Eastern Europe: Successes Achieved, New Frontiers Ahead.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  17. Review
  18. Article
  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 16 institutions in 11 countries.

Artur Francisco Schumacher-SchuhDepartamento de Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.ORCID https://orcid.org/0000-0002-8722-0908
Andrei BiegerGraduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.ORCID https://orcid.org/0000-0002-6669-2834
Olaitan OkunoyeDepartment of Clinical and Movement Neurosciences, Queen Square Institute of Neurology, University College London, United Kingdom.ORCID https://orcid.org/0000-0003-0758-0987
Kin Ying MokDepartment of Neurodegenerative Disease and UK Dementia Research Institute, University College of London, London, United Kingdom.ORCID https://orcid.org/0000-0003-3145-880X
Shen-Yang LimDivision of Neurology, Department of Medicine, and the Mah Pooi Soo & Tan Chin Nam Centre for Parkinson's & Related Disorders, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.ORCID https://orcid.org/0000-0002-6942-2522
Soraya BardienDivision of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-3508-3438
Azlina Ahmad-AnnuarDepartment of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Bruno Lopes Santos-LobatoLaboratório de Neuropatologia Experimental, Universidade Federal do Pará, Belém, Brazil.ORCID https://orcid.org/0000-0001-9321-5710
Matheus Zschornack StrelowGraduate Program in Medicine: Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Mohamed SalamaInstitute of Global Health and Human Ecology, The American University in Cairo, Cairo, Egypt.ORCID https://orcid.org/0000-0003-1644-0273
Shilpa C RaoGenomic Medicine Institute, Lerner Research Institute, Genomic Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0002-2284-9203
Yared Zenebe ZewdeDepartment of Neurology, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.ORCID https://orcid.org/0000-0002-6442-7148
Saiesha DindayalDivision of Neurology, Department of Neurosciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0002-9140-9359
Jihan AzarInstitute of Global Health and Human Ecology, The American University in Cairo, Cairo, Egypt.ORCID https://orcid.org/0000-0002-1604-3529
Lingappa Kukkle PrashanthCenter for Parkinson's Disease and Movement Disorders, Manipal Hospital, Bangalore, India.ORCID https://orcid.org/0000-0002-4610-947X
Roopa RajanDepartment of Neurology, All India Institute of Medical Sciences (AIIMS), New Delhi, India.ORCID https://orcid.org/0000-0003-4987-7252
Alastair J NoycePreventive Neurology Unit, Centre for Prevention, Detection and Diagnosis, Wolfson Institute of Population Health, Queen Mary University of London, London, United Kingdom.ORCID https://orcid.org/0000-0003-3027-5497
Njideka OkubadejoDepartment of Medicine, College of Medicine, University of Lagos, Lagos State, Nigeria.ORCID https://orcid.org/0000-0003-2975-8803
Mie RizigInstitute of Neurology, University College of London, London, United Kingdom.ORCID https://orcid.org/0000-0003-2420-4449
Suzanne LesageSorbonne Université, Institut du Cerveau-Paris Brain Institute-ICM, INSERM, CNRS, Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, CIC Neurosciences, Paris, France.
Ignacio Fernandez MataGenomic Medicine Institute, Lerner Research Institute, Genomic Medicine, Cleveland Clinic Foundation, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0003-1198-0633
Global Parkinson's Genetics Program (GP2)
Universidade Federal do Rio Grande do Sul · BRAmerican University in Cairo · EGCleveland Clinic · USUniversity of Malaya · MYAddis Ababa University · ETAll India Institute of Medical Sciences · INCentre National de la Recherche Scientifique · FRHong Kong University of Science and Technology · HKManipal Hospital · INNational Hospital for Neurology and Neurosurgery · GBQueen Mary University of London · GBStellenbosch University · ZAUniversidade Federal do Pará · BRUniversity College London · GBUniversity of Lagos · NGUniversity of the Witwatersrand · ZA

Funding

Modeling the impact of Women's Specific Health Factors in PD outcomes in LatinasR01NS112499 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI FERNANDEZ MATA, IGNACIO · 2020 to 2024
$3.3M
6 · The paper itself

Abstract

backgroundHuman genetics research lacks diversity; over 80% of genome-wide association studies have been conducted on individuals of European ancestry. In addition to limiting insights regarding disease mechanisms, disproportionate representation can create disparities preventing equitable implementation of personalized medicine.

objectiveThis systematic review provides an overview of research involving Parkinson's disease (PD) genetics in underrepresented populations (URP) and sets a baseline to measure the future impact of current efforts in those populations.

methodsWe searched PubMed and EMBASE until October 2021 using search strings for "PD," "genetics," the main "URP," and and the countries in Latin America, Caribbean, Africa, Asia, and Oceania (excluding Australia and New Zealand). Inclusion criteria were original studies, written in English, reporting genetic results on PD from non-European populations. Two levels of independent reviewers identified and extracted information.

resultsWe observed imbalances in PD genetic studies among URPs. Asian participants from Greater China were described in the majority of the articles published (57%), but other populations were less well studied; for example, Blacks were represented in just 4.0% of the publications. Also, although idiopathic PD was more studied than monogenic forms of the disease, most studies analyzed a limited number of genetic variants. We identified just nine studies using a genome-wide approach published up to 2021, including URPs.

conclusionThis review provides insight into the significant lack of population diversity in PD research highlighting the immediate need for better representation. The Global Parkinson's Genetics Program (GP2) and similar initiatives aim to impact research in URPs, and the early metrics presented here can be used to measure progress in the field of PD genetics in the future. © 2022 International Parkinson and Movement Disorder Society.

Indexed as

Parkinson DiseaseChinaForecastingGenome-Wide Association StudyHumansNew ZealanddiversitygeneticsParkinson's diseasesystematic reviewunderrepresented populations

Identifiers

PMID35867623
PMCPMC10360137
OpenAlexW4286586502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.