ReviewChemSusChem2022
Mechanochemistry: New Tools to Navigate the Uncharted Territory of "Impossible" Reactions.
Review in ChemSusChem, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed.
- Mechanochemical Amidation Mediated by 1,1'-Oxalyldiimidazole for the Synthesis of Agrochemicals.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Identifying new solid forms of a labile pharmaceutical compound by additive assisted mechanochemistry.RSC mechanochemistry · 2026Article
- From ball-milling to bead-milling technology: rapid optimization and scale-up of a one-pot Wittig olefination-Diels-Alder reaction sequence using an agitator bead mill.RSC mechanochemistry · 2026Article
- Mechanochemical Integration of Incompatible Reaction Environments for the One-Pot Synthesis of Structurally Diverse N-Heterocycles.ChemSusChem · 2026Article
- Reinventing the Corey-Fuchs Reaction under Ball Milling Conditions: A Mechanochemical Pathway to Bromoalkynes.ACS omega · 2026Article
- Machine learning-assisted development of a fast Mechanochemical Johnson-Corey-Chaykovsky reaction.Nature communications · 2026Article
- Mechanochemical Dehydrogenative Phenochalcogenazination: A Pronounced Water Effect.ChemSusChem · 2026Article
- Mechanochemical Methods for Amide Bond Formation.Chemical reviews · 2026Review
- Mechanochemical Single-Carbon Insertion into (Iso)quinolines.Nature communications · 2026Article
- Mechanochemically Synthesized Amidetriazoles for Effective Optical and Electrochemical Detection of Anions.The Journal of organic chemistry · 2026Article
- Closing the Loop on Polyurethane Foam Waste: Challenges, Emerging Technologies, and the Road to Sustainable Circularity.ACS sustainable chemistry & engineering · 2026Review
- Mechanochemistry for Metal-Organic Frameworks and Covalent-Organic Frameworks (MOFs, COFs): Methods, Materials, and Mechanisms.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Mechanochemical Dehalogenative Deuteration of Alkyl Halides Through Piezoelectric Catalysis Initiated by a Single-Electron Oxidation Strategy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Computational Model to Predict Reactivity under Ball-Milling Conditions.Journal of chemical theory and computation · 2025Article
- Mechanochemical Strategies Applied to the Late-Stage Modifications of Pharmaceutically Active Compounds.Angewandte Chemie (International ed. in English) · 2025Review
- Tech-Enhanced Synthesis: Exploring the Synergy between Organic Chemistry and Technology.Journal of the American Chemical Society · 2025Review
- Mechanoactivated Celite as a Catalyst for C‒H Bond Perfluoroalkylation and Other Radical Reactions.Angewandte Chemie (International ed. in English) · 2025Article
- Mechanochemical Approach for Metal-Free Regioselective C5-Sulfenylation of Imidazo[2,1-b]Thiazoles.ChemSusChem · 2025Article
- Mechanochemistry-Driven Borrowing Hydrogen Processes for Ru-Catalyzed N-Alkylation: A Pathway to Enhanced Sustainability and Efficiency.Angewandte Chemie (International ed. in English) · 2025Article
- Vapor-Assisted Mechanochemical Synthesis of Enzyme and Hydrogen-Bonded Organic Framework Biocomposites.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Mechanochemical transformations have made chemists enter unknown territories, forcing a different chemistry perspective. While questioning or revisiting familiar concepts belonging to solution chemistry, mechanochemistry has broken new ground, especially in the panorama of organic synthesis. Not only does it foster new "thinking outside the box", but it also has opened new reaction paths, allowing to overcome the weaknesses of traditional chemistry exactly where the use of well-established solution-based methodologies rules out progress. In this Review, the reader is introduced to an intriguing research subject not yet fully explored and waiting for improved understanding. Indeed, the study is mainly focused on organic transformations that, although impossible in solution, become possible under mechanochemical processing conditions, simultaneously entailing innovation and expanding the chemical space.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.