Evidence map›Paper›PMID 35867560›Full record

ArticleJournal of virology2022

Establishment, Persistence, and Reactivation of Latent HIV-1 Infection in Renal Epithelial Cells.

Erich J Baker, Kelly Hughes, Tatianna Travieso, Mary E Klotman, Maria Blasi

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Erich J BakerDepartment of Medicine, Duke Universitygrid.26009.3d School of Medicine, Durham, North Carolina, USA.
Kelly HughesDepartment of Medicine, Duke Universitygrid.26009.3d School of Medicine, Durham, North Carolina, USA.
Tatianna TraviesoDepartment of Medicine, Duke Universitygrid.26009.3d School of Medicine, Durham, North Carolina, USA.
Mary E KlotmanDepartment of Medicine, Duke Universitygrid.26009.3d School of Medicine, Durham, North Carolina, USA.
Maria BlasiDepartment of Medicine, Duke Universitygrid.26009.3d School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-7091-0312
Duke University · US

Funding

VIRAL PATHOGENESIS OF HIV ASSOCIATED NEPHROPATHYP01DK056492 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI KLOTMAN, MARY E. · 1999 to 2021
$27.8M
The Genitourinary Tract as a compartment and reservoir for HIVR01DK108367 · NIDDK · DUKE UNIVERSITY · PI KLOTMAN, MARY E. · 2015 to 2019
$2.4M
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) P01DK056492HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK108367NIDDK NIH HHS P01 DK056492NIDDK NIH HHS R01 DK108367
6 · The paper itself

Abstract

HIV-1 persistence in different cell types presents the main obstacle to an HIV-1 cure. We have previously shown that the renal epithelium is a site of HIV-1 infection and that the kidney represents a separate viral compartment from blood. Whether renal cells can harbor latent virus that can be reactivated upon treatment with latency reversing agents (LRAs) is unknown. To address this question, we developed an

Indexed as

Epithelial CellsHIV InfectionsKidneyVirus ActivationVirus LatencyCD4-Positive T-LymphocytesCells, CulturedHIV-1HumansHIV-1latencyLRAsrenal epithelial cellsreservoir

Identifiers

PMID35867560
PMCPMC9327708
OpenAlexW4283807560

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.