Evidence map›Paper›PMID 35867408›Full record

ArticleMicrobiology spectrum2022

Analysis of Intestinal Mycobiota of Patients with Clostridioides difficile Infection among a Prospective Inpatient Cohort.

Yangchun Cao, Lamei Wang, Shanlin Ke, Ciarán P Kelly, Nira R Pollock, Javier A Villafuerte Gálvez, Kaitlyn Daugherty, Hua Xu, Junhu Yao, Yulin Chen and 2 more

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. iMetaOmics · 2025
    Review
  2. A comprehensive guide to assess gut mycobiome and its role in pathogenesis and treatment of inflammatory bowel disease.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024
    Review
  3. Review
  4. Fungal and bacterial gut microbiota differ betweenMicrobiome research reports · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Oral Fungal Alterations in Patients with COVID-19 and Recovered Patients.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Yangchun Cao *College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi Province, China.ORCID 0000-0003-1033-2909
Lamei Wang *College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi Province, China.
Shanlin Ke *Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Ciarán P KellyDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Centergrid.239395.7, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Nira R PollockDivision of Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Centergrid.239395.7, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.ORCID 0000-0002-6396-2915
Javier A Villafuerte GálvezDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Centergrid.239395.7, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Kaitlyn DaughertyDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Centergrid.239395.7, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Hua XuDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Centergrid.239395.7, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Junhu YaoCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi Province, China.
Yulin ChenCollege of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi Province, China.
Yang-Yu LiuChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.
Xinhua ChenDivision of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Centergrid.239395.7, Harvard Medical Schoolgrid.471403.5, Boston, Massachusetts, USA.ORCID 0000-0002-3944-3816
Beth Israel Deaconess Medical Center · USBrigham and Women's Hospital · USNorthwest A&F University · CNBoston Children's Hospital · US

Funding

Therapeutic Control of Aspirin-Exacerbated Respiratory DiseaseU19AI095219 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI Tanya Maria Laidlaw · 2011 to 2026
$29.1M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
Multi-omic approaches to mechanisms of vitamin D, environmental influences, and the microbiome on asthmaUH3OD023268 · OD · BRIGHAM AND WOMEN'S HOSPITAL · PI LITONJUA, AUGUSTO A, WEISS, SCOTT T · 2018 to 2022
$13.5M
Prospective Study of the Gut Microbiome in AgingRF1AG067744 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI CHAN, ANDREW T · 2020 to 2020
$11.7M
RESEARCH TRAINING IN GASTROENTEROLOGYT32DK007760 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KELLY, CIARAN P · 1999 to 2019
$4.6M
Functional Redundancy of Human Microbiome and its Implication in Fecal Microbiota TransplantationR01AI141529 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI LIU, YANG-YU · 2019 to 2023
$4.5M
Ultrasensitive C.difficile toxin measurement for diagnosis and outcome predictionR01AI116596 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI POLLOCK, NIRA · 2016 to 2020
$4.1M
Long-term health consequences of birth by cesarean sectionR01HD093761 · NICHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI CHAVARRO, JORGE EDUARDO · 2018 to 2022
$3.3M
NHLBI NIH HHS U01 HL089856NIAID NIH HHS R01 AI116596NIAID NIH HHS R01 AI141529NIAID NIH HHS U19 AI095219NIA NIH HHS RF1 AG067744NICHD NIH HHS R01 HD093761NIDDK NIH HHS T32 DK007760NIH HHS UH3 OD023268
6 · The paper itself

Abstract

Clostridioides difficile infection (CDI) is a burden to health care systems worldwide. Gut microbiota dysbiosis associated with CDI has been well accepted. However, contribution of fungal mycobiota to CDI has recently gained research interest. Here, we report the gut mycobiota composition of 149 uniquely well characterized participants from a prospective clinical cohort and evaluate the discriminating ability of gut mycobiota to classify CDI and non-CDI patients. Fecal samples were divided into two groups: (i) CDI (inpatients who had clinically significant diarrhea and positive nucleic acid amplification testing [NAAT] and received subsequent CDI therapy,

Indexed as

Clostridioides difficileClostridium InfectionsDiarrheaEcosystemHumansInpatientsProspective StudiesbiomarkerClostridiodes difficilediarrheagut mycobiotaITS2

Identifiers

PMID35867408
PMCPMC9430669
OpenAlexW4285495150

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.