ArticleArchives of microbiology2022
Comparative transcriptome analysis revealed candidate genes involved in fruiting body development and sporulation in Ganoderma lucidum.
Article in Archives of microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 20 citations in OpenAlex.
- Molecular biology of Pleurotus mushrooms: genomic resources, genetic manipulation, and regulation mechanisms.Antonie van Leeuwenhoek · 2026Review
- Comparative Transcriptome Analysis Revealed Candidate Genes Involved in Fruiting Body Development in the culinary-medicinal Mushroom Pleurotus tuber-regium.Current microbiology · 2026Article
- Transcriptomic analysis ofFrontiers in fungal biology · 2026Article
- Identification of Critical Candidate Genes Controlling Monokaryon Fruiting inJournal of fungi (Basel, Switzerland) · 2025Article
- Genome-wide identification and expression analysis of epigenetic regulator gene families in the medicinal mushroom Ganoderma lucidum.Archives of microbiology · 2025Article
- Sexual spores in mushrooms: bioactive compounds, factors and molecular mechanisms of spore formation.Archives of microbiology · 2025Review
- Transcriptome analysis reveals key genes and pathways associated with heat stress in Pleurotus pulmonarius.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- High-Yield-Related Genes Participate in Mushroom Production.Journal of fungi (Basel, Switzerland) · 2024Review
- Research hotspots and emerging trends in growth and development of macrofungi: a bibliometric review based on CiteSpace analysis.World journal of microbiology & biotechnology · 2024Review
- Screening of the Candidate Metabolite to Evaluate the Mycelium Physiological Maturation ofJournal of fungi (Basel, Switzerland) · 2024Article
- Identification and Characterization of a Predominant Hydrophobin in the Edible MushroomJournal of fungi (Basel, Switzerland) · 2023Article
- Application of Miscanthus substrates in the cultivation of Ganoderma lingzhi.Archives of microbiology · 2023Article
- Transcription factors: switches for regulating growth and development in macrofungi.Applied microbiology and biotechnology · 2023Review
- Article
- Comparative analysis of proteomes and transcriptomes revealed the molecular mechanism of development and nutrition ofFrontiers in nutrition · 2023Article
- Transcriptome Profiling Reveals Candidate Genes Related to Stipe Gradient Elongation ofJournal of fungi (Basel, Switzerland) · 2022Article
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Authors and funding
11 authors at 3 institutions in 1 country.
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Abstract
Ganoderma lucidum is an edible mushroom highly regarded in the traditional Chinese medicine. To better understand the molecular mechanisms underlying fruiting body development in G. lucidum, transcriptome analysis based on RNA sequencing was carried out on different developmental stages: mycelium (G1); primordium (G2); young fruiting body (G3); mature fruiting body (G4); fruiting body in post-sporulation stage (G5). In total, 26,137 unigenes with an average length of 1078 bp were de novo assembled. Functional annotation of transcriptomes matched 72.49% of the unigenes to known proteins available in at least one database. Differentially expressed genes (DEGs) were identified between the evaluated stages: 3135 DEGs in G1 versus G2; 120 in G2 versus G3; 3919 in G3 versus G4; and 1012 in G4 versus G5. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of DEGs identified in G1 versus G2 revealed that, in addition to global and overview maps, enriched pathways were related to amino acid metabolism and carbohydrate metabolism. In contrast, DEGs identified in G2 versus G3 were mainly assigned to the category of metabolism of amino acids and their derivatives, comprising mostly upregulated unigenes. In addition, highly expressed unigenes associated with the transition between different developmental stages were identified, including those encoding hydrophobins, cytochrome P450s, extracellular proteases, and several transcription factors. Meanwhile, highly expressed unigenes related to meiosis such as DMC1, MSH4, HOP1, and Mek1 were also analyzed. Our study provides important insights into the molecular mechanisms underlying fruiting body development and sporulation in G. lucidum.
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