SynthesisArchives of women's mental health2022
Premenstrual exacerbation of mental health disorders: a systematic review of prospective studies.
Synthesis in Archives of women's mental health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- A scoping review of hormonal clinical trials in menstrual cycle-related brain disorders: Studies in premenstrual mood disorder, menstrual migraine, and catamenial epilepsy.Frontiers in neuroendocrinology · 2023Pooled it
- Effects of estrogen and progesterone on neuroactive steroids and cytokines in patients with suicidality.Psychoneuroendocrinology · 2023Trial
- Post stress sensory contact with a male mouse is associated with altered social behavior in a female vicarious social defeat stress model.Experimental animals · 2026Article
- "Controlled by Female Hormones": A Qualitative Interview Study of Swedish Women's Experiences of Gender-Specific Aspects of Life With ADHD.Journal of attention disorders · 2026Article
- Affective Sensitivity to Ovarian Steroid Hormone Flux Across the Menstrual Cycle: Manifestations and Biopsychosocial Risk Factors.Annual review of clinical psychology · 2026Review
- Molecular Mechanisms of Menstrual Cycle-Related Suicide Risk: A Selective Review of Promising Candidate Systems.Biological psychiatry · 2026Review
- Peripheral cyclical expression of GABA-A receptor subunit genes and menstrual cycle affective change: a dimensional, transdiagnostic study.Translational psychiatry · 2025Article
- Self-Guided Mental Health Interventions for Premenstrual Mood Symptoms.Current psychiatry reports · 2025Review
- Premenstrual Dysphoric Disorder Prevalence and Symptoms Across Age Groups: A Cross-Sectional Study.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- The menstrual cycle is a vital sign across the lifespan.The Lancet. Obstetrics, gynaecology, & women's health · 2025Article
- Toward Precision Reproductive Psychiatry: A Call for Targeted, Transdiagnostic Approaches to Premenstrual Disorders.The American journal of psychiatry · 2025Article
- Job Stress, Psychological Distress, and Menstruation-Related Symptoms in Female Workers: A Cross-Sectional Study.BJOG : an international journal of obstetrics and gynaecology · 2025Article
- Unmasking the cycle: Premenstrual and menstrual exacerbation of psychiatric disorders and impact on female mental health.World journal of psychiatry · 2025Review
- Tracking mood symptoms across the menstrual cycle in women with depression using ecological momentary assessment and heart rate variability.BMJ mental health · 2025Article
- The Menstrual Cycle as a Vital Sign: a comprehensive review.F&S reviews · 2025Article
- Women's reproductive mental health: currently available evidence and future directions for research, clinical practice and health policy.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- The impact of reproductive events on women with severe mental illness: we need more research and professional awareness.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- The menstrual cycle: an overlooked vital sign in psychiatry?BMJ mental health · 2025Article
- Article
- Dimensional Affective Sensitivity to Hormones across the Menstrual Cycle (DASH-MC): A transdiagnostic framework for ovarian steroid influences on psychopathology.Molecular psychiatry · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mental health disorders can be exacerbated during periods of hormonal fluctuation (e.g. pregnancy, menopause), and the risk factors for sensitivity to these fluctuations are similar to those of mental disorders (e.g. trauma). However, the extent to which hormonal fluctuations during the menstrual cycle impact symptoms of preexisting mental disorders remains unclear. Prospective methodology is considered the gold standard for measuring symptoms across the menstrual cycle. Thus, the aim of the review was to address this knowledge gap by summarising all available studies prospectively measuring symptoms of mental disorders across the menstrual cycle. A systematic review with narrative synthesis was conducted; meta-analysis was precluded due to methodological heterogeneity of included studies. Electronic databases MEDLINE, Embase, PyschINFO and CINAHL were systematically searched from inception. Risk of bias for individual studies was assessed using a modified version of the Newcastle-Ottawa Scale. The search identified 629 studies from which 35 met inclusion criteria. There was clear evidence of symptom exacerbation during the perimenstrual phase for psychotic disorders, panic disorder, eating disorders, depression and borderline personality disorder. Less consistent evidence was found for anxiety, and a different pattern of symptom exacerbation was observed in bipolar disorder. Sample size and methodology varied considerably amongst studies. Overall, there was mixed evidence for perimenstrual exacerbation across mental disorders, which could be partly explained by methodological limitations of the studies. However, hormonal fluctuations during the menstrual cycle may exacerbate psychiatric symptoms in a subgroup of individuals who are hormone sensitive.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.