ArticleAbdominal radiology (New York)2022
Pre- and post-therapeutic evaluation of liver and spleen in type I and type III Gaucher's disease using diffusion tensor imaging.
Article in Abdominal radiology (New York), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 2 citations in OpenAlex.
- 3.0 T diffusion tensor imaging and fiber tractography of the testes in nonobstructive azoospermia.Abdominal radiology (New York) · 2024Article
- Diffusion tensor imaging and fiber tractography of the normal epididymis.Abdominal radiology (New York) · 2024Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
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Abstract
purposeTo assess the role of diffusion tensor imaging in assessing liver and splenic parenchymal infiltration in Gaucher's disease (G.D.) type I and III before and after therapy.
methodsA prospective study was conducted upon 28 consecutive patients with G.D. type I and III and 28 age and sex-matched controls. They underwent an MRI and DTI of the liver and spleen. Mean diffusivity (M.D.) and fractional anisotropy (F.A.) values of the liver and spleen were evaluated before and after treatment and compared with control.
resultsThere was a statistically significant difference in the M.D. value of the liver and spleen between untreated patients and controls and between control and treated patients and in the M.D. value of the liver and spleen between untreated and treated patients. There is a statistically significant difference in the F.A. value of the liver and spleen between untreated patients and controls and in the F.A. value of the liver and spleen between untreated and treated patients. Hemoglobin level was positively correlated with the M.D. value of the spleen. Clinical score was negatively correlated with M.D. value of the spleen and was positively correlated with F.A. values of the liver and F.A. values of the spleen. Spleen volume was negatively correlated with M.D. values of the spleen.
conclusionSignificant difference in M.D. and F.A. values of liver and splenic parenchyma in p atients with type I and III G.D. and controls, and between untreated and treated patients. The M.D. and F.A. values were well correlated with some biomarkers of disease activity.
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