Evidence map›Paper›PMID 35867070›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2022

Abnormal levels of mitochondrial Ca

Edward J Goetzl, Vinod H Srihari, Maja Mustapic, Dimitrios Kapogiannis, George R Heninger

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
  2. The chromosome-level genome of Chinese indicine cattle breed provides insights into bovine adaptation and immunity.DNA research : an international journal for rapid publication of reports on genes and genomes · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
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  9. Article
  10. Article
  11. Review
  12. Research progress in role of exosomes exosomes in mental disorders.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
    Article
  13. An NIMH Workshop on Non-Affective Psychosis in Midlife and Beyond: Research Agenda on Phenomenology, Clinical Trajectories, Underlying Mechanisms, and Intervention Targets.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Edward J GoetzlDepartment of Medicine, University of California Medical Center, San Francisco, California, USA.ORCID 0000-0002-0706-5371
Vinod H SrihariDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Maja MustapicIntramural Research Program, National Institute on Aging, Biomedical Research Center, Baltimore, Maryland, USA.
Dimitrios KapogiannisIntramural Research Program, National Institute on Aging, Biomedical Research Center, Baltimore, Maryland, USA.
George R HeningerDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Institute on Aging · USYale University · USUniversity of California San Francisco Medical Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Studies in Dementia and Neurodegenerative DiseasesZIAAG000975 · NIA · NATIONAL INSTITUTE ON AGING · PI KAPOGIANNIS, DIMITRIOS · 2009 to 2025
$31.5M
STEP-ED:Reducing Duration of Untreated Psychosis and its Impact in the U.S.R01MH103831 · NIMH · YALE UNIVERSITY · PI SRIHARI, VINOD H. · 2013 to 2017
$3.9M
Intramural NIH HHS Z99 AG999999Intramural NIH HHS ZIA AG000975NCATS NIH HHS UL1 TR001863NIMH NIH HHS R01 MH103831
6 · The paper itself

Abstract

Structural alterations or quantitative abnormalities of some mitochondrial ion channels and exchangers are associated with altered neuronal functions and increased susceptibility to mental illness. Here we have assessed levels of functionally prominent mitochondrial calcium ion channel proteins in plasma neuron-derived extracellular vesicles (NDEVs) of living patients with first episodes of psychosis (FP) and matched controls (Cs). NDEVs were enriched with an established method of precipitation and immunoabsorption by anti-human CD171 neural adhesion protein (L1CAM) antibody and extracted proteins quantified with ELISAs. CD81 exosome marker-normalized NDEV levels of leucine zipper EF-hand containing transmembrane 1 protein (LETM1), transient receptor potential cation channel subfamily M, member 4 (TRPM4), and solute carrier family 8 member B1 (SLC24A6) or mitochondrial Na

Indexed as

Extracellular VesiclesMajor Depressive DisorderSchizophreniaCalciumGenome-Wide Association StudyHumansMembrane ProteinsMitochondrial ProteinsNeuronsSodium-Calcium ExchangerCalciumMembrane ProteinsMitochondrial ProteinsSodium-Calcium Exchangerbiomarkerscalcium homeostasismental illnesspsychosis

Identifiers

PMID35867070
PMCPMC9358927
OpenAlexW4286486144

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.