Evidence map›Paper›PMID 35867061›Full record

ArticleJAMA network open2022

Post-COVID-19 Conditions Among Children 90 Days After SARS-CoV-2 Infection.

Anna L Funk, Nathan Kuppermann, Todd A Florin, Daniel J Tancredi, Jianling Xie, Kelly Kim, Yaron Finkelstein, Mark I Neuman, Marina I Salvadori, Adriana Yock-Corrales and 44 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in JAMA network open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 73 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
73citing papers in PubMed, 8 pooled it
13.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

73 citing papers in PubMed, 8 syntheses or guidelines pooled it, 112 citations in OpenAlex.

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13 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

54 authors at 20 institutions in 10 countries.

Anna L FunkDepartment of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Nathan KuppermannDepartment of Emergency Medicine, University of California, Davis School of Medicine, Sacramento.
Todd A FlorinDepartment of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Daniel J TancrediDepartment of Pediatrics, University of California, Davis School of Medicine, Sacramento.
Jianling XieDepartment of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Kelly KimDepartment of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Yaron FinkelsteinDivision of Emergency Medicine, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
Mark I NeumanDepartment of Pediatrics, Harvard Medical School, Boston, Massachusetts.
Marina I SalvadoriDepartment of Pediatrics, McGill University, Montreal, Quebec, Canada.
Adriana Yock-CorralesEmergency Department, Hospital Nacional de Niños "Dr. Carlos Sáenz Herrera," CCSS, San José, Costa Rica.
Kristen A BreslinDepartment of Emergency Medicine and Trauma Services, Children's National Hospital, Washington, DC.
Lilliam AmbroggioDepartment of Pediatrics, University of Colorado, Aurora.
Pradip P ChaudhariDivision of Emergency and Transport Medicine, Children's Hospital Los Angeles and Keck School of Medicine of the University of Southern California, Los Angeles.
Kelly R BergmannDepartment of Emergency Medicine, Children's Minnesota, Minneapolis.
Michael A GardinerDepartment of Pediatrics, University of California, San Diego, Rady Children's Hospital, San Diego.
Jasmine R NebhrajaniDepartment of Pediatrics, St Mary's Medical Center, West Palm Beach, Florida.
Carmen CamposPediatric Emergency Department, Hospital Universitario Miguel Servet, Zaragoza, Spain.
Fahd A AhmadDepartment of Pediatrics, Washington University in St Louis School of Medicine, St Louis, Missouri.
Laura F SartoriDivision of Pediatric Emergency Medicine, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Nidhya NavanandanDepartment of Pediatrics, University of Colorado, Aurora.
Nirupama KannikeswaranDivision of Emergency Medicine, Children's Hospital of Michigan, Detroit.
Kerry CaperellDepartment of Pediatrics, University of Louisville, Louisville, Kentucky.
Claudia R MorrisDepartment of Pediatrics, Division of Pediatric Emergency Medicine, Emory University School of Medicine, Children's Healthcare of Atlanta, Atlanta, Georgia.
Santiago MintegiPediatric Emergency Department, Biocruces Bizkaia Health Research Institute, Hospital Universitario Cruces, University of the Basque Country, UPV/EHU Bilbao, Basque Country, Spain.
Iker GangoitiPediatric Emergency Department, Biocruces Bizkaia Health Research Institute, Hospital Universitario Cruces, University of the Basque Country, UPV/EHU Bilbao, Basque Country, Spain.
Vikram J SabhaneyDepartment of Paediatrics, University of British Columbia, Vancouver, British Columbia, Canada.
Amy C PlintDivision of Emergency Medicine, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Terry P KlassenChildren's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada.
Usha R AvvaDepartment of Emergency Medicine, Montefiore-Nyack Hospital, Nyack, New York.
Nipam P ShahDivision of Pediatric Emergency Medicine, Department of Pediatrics, University of Alabama at Birmingham.
Andrew C DixonUniversity of Alberta, Stollery Children's Hospital, Women's and Children's Health Research Institute, Edmonton, Alberta, Canada.
Maren M LunoeUPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
Sarah M BeckerPrimary Children's Hospital, Intermountain Healthcare, Salt Lake City, Utah.
Alexander J RogersDepartment of Emergency Medicine, University of Michigan School of Medicine, Ann Arbor.
Viviana PavlicichDepartamento de Emergencia Pediátrica, Hospital General Pediátrico Niños de Acosta Ñu, Facultad de Medicina, Universidad Privada del Pacífico, San Lorenzo, Paraguay.
Stuart R DalzielChildren's Emergency Department, Starship Children's Hospital, Auckland, New Zealand.
Daniel C PayneCenters for Disease Control and Prevention, Atlanta, Georgia.
Richard MalleyDivision of Infectious Diseases, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.
Meredith L BorlandEmergency Department, Perth Children's Hospital, Perth, Western Australia.
Andrea K MorrisonDivision of Emergency Medicine, Department of Pediatrics, Medical College of Wisconsin, Milwaukee.
Maala BhattDepartment of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
Pedro B RinoHospital de Pediatría "Prof Dr. Juan P. Garrahan," RIDEPLA, Buenos Aires, Argentina.
Isabel Beneyto FerreDepartment of Pediatrics, Hospital Francesc de Borja, Gandia, Spain.
Michelle EckerleDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
April J KamDepartment of Pediatrics, Division of Emergency Medicine, McMaster Children's Hospital, Hamilton, Ontario, Canada.
Shu-Ling ChongDepartment of Emergency Medicine, KK Women's and Children's Hospital, Duke-NUS Medical School, SingHealth Duke-NUS Global Health Institute, Singapore.
Laura PalumboASST Spedali Civili di Brescia-Pronto soccorso pediatrico, Brescia, Italy.
Maria Y KwokDepartment of Emergency Medicine, New York Presbyterian Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, New York.
Jonathan C CherryDepartment of Pediatric Emergency Medicine, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada.
Naveen PoonaiDepartment of Pediatrics, Schulich School of Medicine & Dentistry, London, Ontario, Canada.
Muhammad WaseemDepartment of Emergency Medicine, Lincoln Medical Center, New York, New York.
Norma-Jean SimonDivision of Emergency Medicine, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Stephen B FreedmanSection of Pediatric Emergency Medicine, Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Pediatric Emergency Research Network–COVID-19 Study Team
Research Network (United States) · USUniversity of Calgary · CABioCruces Health research Institute · ESChildren's Hospital of Eastern Ontario · CAUniversity of California, Davis · USUniversity of Colorado Denver · USAzienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia · ITBoston Children's Hospital · USCenters for Disease Control and Prevention · USChildren's Healthcare of Atlanta · USChildren's Hospital of Los Angeles · USChildren's Hospital of Michigan · USChildren's Hospital of Philadelphia · USChildren's Hospital of Pittsburgh · USChildren's Hospital Research Institute of Manitoba · CAChildren's Minnesota · USChildren's National · USCincinnati Children's Hospital Medical Center · USColumbia University · USGarrahan Hospital · AR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Importance: Little is known about the risk factors for, and the risk of, developing post-COVID-19 conditions (PCCs) among children. Objectives: To estimate the proportion of SARS-CoV-2-positive children with PCCs 90 days after a positive test result, to compare this proportion with SARS-CoV-2-negative children, and to assess factors associated with PCCs. Design, Setting, and Participants: This prospective cohort study, conducted in 36 emergency departments (EDs) in 8 countries between March 7, 2020, and January 20, 2021, included 1884 SARS-CoV-2-positive children who completed 90-day follow-up; 1686 of these children were frequency matched by hospitalization status, country, and recruitment date with 1701 SARS-CoV-2-negative controls. Exposure: SARS-CoV-2 detected via nucleic acid testing. Main Outcomes and Measures: Post-COVID-19 conditions, defined as any persistent, new, or recurrent health problems reported in the 90-day follow-up survey. Results: Of 8642 enrolled children, 2368 (27.4%) were SARS-CoV-2 positive, among whom 2365 (99.9%) had index ED visit disposition data available; among the 1884 children (79.7%) who completed follow-up, the median age was 3 years (IQR, 0-10 years) and 994 (52.8%) were boys. A total of 110 SARS-CoV-2-positive children (5.8%; 95% CI, 4.8%-7.0%) reported PCCs, including 44 of 447 children (9.8%; 95% CI, 7.4%-13.0%) hospitalized during the acute illness and 66 of 1437 children (4.6%; 95% CI, 3.6%-5.8%) not hospitalized during the acute illness (difference, 5.3%; 95% CI, 2.5%-8.5%). Among SARS-CoV-2-positive children, the most common symptom was fatigue or weakness (21 [1.1%]). Characteristics associated with reporting at least 1 PCC at 90 days included being hospitalized 48 hours or more compared with no hospitalization (adjusted odds ratio [aOR], 2.67 [95% CI, 1.63-4.38]); having 4 or more symptoms reported at the index ED visit compared with 1 to 3 symptoms (4-6 symptoms: aOR, 2.35 [95% CI, 1.28-4.31]; ≥7 symptoms: aOR, 4.59 [95% CI, 2.50-8.44]); and being 14 years of age or older compared with younger than 1 year (aOR, 2.67 [95% CI, 1.43-4.99]). SARS-CoV-2-positive children were more likely to report PCCs at 90 days compared with those who tested negative, both among those who were not hospitalized (55 of 1295 [4.2%; 95% CI, 3.2%-5.5%] vs 35 of 1321 [2.7%; 95% CI, 1.9%-3.7%]; difference, 1.6% [95% CI, 0.2%-3.0%]) and those who were hospitalized (40 of 391 [10.2%; 95% CI, 7.4%-13.7%] vs 19 of 380 [5.0%; 95% CI, 3.0%-7.7%]; difference, 5.2% [95% CI, 1.5%-9.1%]). In addition, SARS-CoV-2 positivity was associated with reporting PCCs 90 days after the index ED visit (aOR, 1.63 [95% CI, 1.14-2.35]), specifically systemic health problems (eg, fatigue, weakness, fever; aOR, 2.44 [95% CI, 1.19-5.00]). Conclusions and Relevance: In this cohort study, SARS-CoV-2 infection was associated with reporting PCCs at 90 days in children. Guidance and follow-up are particularly necessary for hospitalized children who have numerous acute symptoms and are older.

Indexed as

COVID-19Acute DiseaseChildChild, PreschoolCohort StudiesFatigueFemaleHumansInfantInfant, NewbornMaleProspective StudiesSARS-CoV-2

Identifiers

PMID35867061
PMCPMC9308058
OpenAlexW4286560128

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.