Evidence map›Paper›PMID 35866869›Full record

ArticleeLife2022

James J Gilchrist, Silvia N Kariuki, James A Watson, Gavin Band, Sophie Uyoga, Carolyne M Ndila, Neema Mturi, Salim Mwarumba, Shebe Mohammed, Moses Mosobo and 8 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. eLife · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 8 countries.

James J GilchristDepartment of Paediatrics, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-2045-6788
Silvia N KariukiKEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.
James A WatsonCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-5524-0325
Gavin BandWellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Sophie UyogaKEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.
Carolyne M NdilaKEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.
Neema MturiKEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.
Salim MwarumbaKEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.
Shebe MohammedKEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.
Moses MosoboKEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.
Kaur AlasooInstitute of Computer Science, University of Tartu, Tartu, Estonia.ORCID 0000-0002-1761-8881
Kirk A RockettWellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Alexander J MentzerWellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Dominic P KwiatkowskiWellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Adrian V S HillWellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
Kathryn MaitlandKEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.ORCID 0000-0002-0007-0645
J Anthony G ScottKEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.ORCID 0000-0001-7533-5006
Thomas N WilliamsKEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research-Coast, Kilifi, Kenya.ORCID 0000-0003-4456-2382
Kenya Medical Research Institute · KECentre for Human Genetics · GBCzech Academy of Sciences, Institute of Computer Science · CZImperial Valley College · USMahidol University · TH

Funding

European Research Council 294557Wellcome Trust 085475/B/08/ZWellcome Trust 098532Wellcome Trust 202800Wellcome Trust 202800/Z/16/ZWellcome Trust 203141/Z/16/ZWellcome Trust 209265/Z/17/ZWellcome Trust 223253/Z/21/ZWellcome Trust HCUZZ0
6 · The paper itself

Abstract

Invasive bacterial disease is a major cause of morbidity and mortality in African children. Despite being caused by diverse pathogens, children with sepsis are clinically indistinguishable from one another. In spite of this, most genetic susceptibility loci for invasive infection that have been discovered to date are pathogen specific and are not therefore suggestive of a shared genetic architecture of bacterial sepsis. Here, we utilise probabilistic diagnostic models to identify children with a high probability of invasive bacterial disease among critically unwell Kenyan children with

Indexed as

BacteremiaBacterial InfectionsMalariaChildGenome-Wide Association StudyHumansInhibitor of Apoptosis ProteinsKenyaBIRC6 protein, humanInhibitor of Apoptosis ProteinsbacteraemiageneticsgenomicsGWAShumaninfectious diseasemalariamicrobiology

Identifiers

PMID35866869
PMCPMC9391038
OpenAlexW4286560772

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.