ArticleArthritis care & research2023
Rheumatoid Arthritis Disease Activity and Hospitalized Infection in a Large US Registry.
Article in Arthritis care & research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 13 citations in OpenAlex.
- Risk of urinary tract infection with SGLT2 inhibitor initiation in patients with immune-mediated inflammatory diseases and type 2 diabetes: A target trial emulation using a Japanese hospital-based claims database.Journal of diabetes investigation · 2026Article
- Causal estimation of time-varying treatments in observational studies: a scoping review of methods, applications, and missing data practices.BMC medical research methodology · 2025Article
- Article
- Factors associated with severe infection in rheumatoid arthritis patients: lessons learned from the COVID-19 pandemic.Infection · 2024Article
- Secondary Immunodeficiency and Vaccine Response in Rheumatoid and Psoriatic Arthritis on Immunosuppressive Medicines.Cureus · 2024Article
- Real-world comparative study of drug retention of Janus kinase inhibitors in patients with rheumatoid arthritis.PloS one · 2024Article
- Reply.Arthritis care & research · 2023Article
- The Impact of b/tsDMARD Dose Reduction on Chronic Hepatitis B in Rheumatoid Arthritis Patients: A Two-Center Long-Term Safety Analysis.Journal of clinical medicine · 2022Article
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7 authors at 5 institutions in 1 country.
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Abstract
objectivesThe association between disease activity and infection risk among patients with rheumatoid arthritis (RA) is not clear, and it is challenging to determine because of confounding due to the effects of RA treatments and comorbidities.
methodsUsing patients with RA in the CorEvitas registry with Medicare coverage in 2006-2019, we identified eligible patients who had at least 1 visit with moderate disease activity based on the Clinical Disease Activity Index (CDAI; CDAI >10 and ≤22). Follow-up started at the subsequent CorEvitas visit. Hospitalized infection during follow-up was assessed in linked Medicare data. We calculated the incidence rate of hospitalized infection for patients in remission, and low and moderate disease activity, and estimated the effect of time-varying CDAI on hospitalized infection by controlling for baseline and time-dependent confounders using marginal structural models (MSMs).
resultsA total of 3,254 patients with RA were eligible for analysis, among which 529 hospitalized infections were identified during follow-up. The crude incidence of hospitalized infection was 3.8 per 100 person-years for patients in remission, 6.6 for low disease activity, and 8.0 for moderate disease activity. Using MSMs and compared with being in remission, the hazard ratio of hospitalized infection associated with low disease activity was 1.60 (95% confidence interval [95% CI] 1.13-2.28) and with moderate disease activity was 1.83 (95% CI 1.30-2.64).
conclusionThe risk of hospitalized infection was higher for patients with RA in low or moderate disease activity than for those in remission after accounting for the interplay of disease activity, RA treatments, treatment switching, and other potential confounders.
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