ArticlePlant physiology2022
Class I TCP transcription factor AtTCP8 modulates key brassinosteroid-responsive genes.
Article in Plant physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 27 citations in OpenAlex.
- The Regulatory Army of Plant Defense: Transcription Factors in the War for Plant Immunity.International journal of molecular sciences · 2026Review
- Dissecting the Cell-Type-Specific Response to an Emerging Tobamovirus in Tomato Reveals Cultivar-Dependent Involvement of Brassinosteroid Signalling.Plant biotechnology journal · 2026Article
- Genome-wide characterization of the TCP family in Lagerstroemia and functional analysis of LfiTCP12 uncover its role in shoot branching promotion.Plant cell reports · 2026Article
- Genome-Wide Identification of thePlants (Basel, Switzerland) · 2026Article
- DSK2-mediated degradation of F-box protein LAO1 and class I TCPs modulates the nitrogen starvation response.EMBO reports · 2025Article
- RTN family and its response to abiotic stress in Oryza sativa.Scientific reports · 2025Article
- Genome-Wide Exploration and Characterization of theInternational journal of molecular sciences · 2025Article
- Mining the Candidate Transcription Factors Modulating Tanshinones' and Phenolic Acids' Biosynthesis Under Low Nitrogen Stress inInternational journal of molecular sciences · 2025Article
- Integrative transcriptome and metabolome analysis reveals candidate genes related to terpene synthesis in Chrysanthemum × morifolium.BMC plant biology · 2025Article
- Genome-wide analysis of the TCP transcription factor family in mung bean and its dynamic regulatory network under salt stress.Frontiers in plant science · 2025Article
- Amaranth's Growth and Physiological Responses to Salt Stress and the Functional Analysis ofInternational journal of molecular sciences · 2024Article
- Article
- Expression of the Arabidopsis redox-related LEA protein, SAG21 is regulated by ERF, NAC and WRKY transcription factors.Scientific reports · 2024Article
- The brassinosteroid-responsive protein OCTOPUS is a novel regulator ofPlant direct · 2023Article
- Article
- Physiological Roles and Mechanisms of Action of Class I TCP Transcription Factors.International journal of molecular sciences · 2023Review
- Advances in Research on the Regulation of Floral Development byCurrent issues in molecular biology · 2023Review
- Genome-wide identification and expression analysis of TCP family genes inFrontiers in plant science · 2023Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plant-specific TEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR (TCP) transcription factor family is most closely associated with regulating plant developmental programs. Recently, TCPs were also shown to mediate host immune signaling, both as targets of pathogen virulence factors and as regulators of plant defense genes. However, comprehensive characterization of TCP gene targets is still lacking. Loss of function of the class I TCP gene AtTCP8 attenuates early immune signaling and, when combined with mutations in AtTCP14 and AtTCP15, additional layers of defense signaling in Arabidopsis (Arabidopsis thaliana). Here, we focus on TCP8, the most poorly characterized of the three to date. We used chromatin immunoprecipitation and RNA sequencing to identify TCP8-bound gene promoters and differentially regulated genes in the tcp8 mutant; these datasets were heavily enriched in signaling components for multiple phytohormone pathways, including brassinosteroids (BRs), auxin, and jasmonic acid. Using BR signaling as a representative example, we showed that TCP8 directly binds and activates the promoters of the key BR transcriptional regulatory genes BRASSINAZOLE-RESISTANT1 (BZR1) and BRASSINAZOLE-RESISTANT2 (BZR2/BES1). Furthermore, tcp8 mutant seedlings exhibited altered BR-responsive growth patterns and complementary reductions in BZR2 transcript levels, while TCP8 protein demonstrated BR-responsive changes in subnuclear localization and transcriptional activity. We conclude that one explanation for the substantial targeting of TCP8 alongside other TCP family members by pathogen effectors may lie in its role as a modulator of BR and other plant hormone signaling pathways.
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