Evidence map›Paper›PMID 35866616›Full record

ReviewACS applied materials & interfaces2023

Real-Time Detection and Visualization of Amyloid-β Aggregates Induced by Hydrogen Peroxide in Cell and Mouse Models of Alzheimer's Disease.

Xueli Wang, Ashok Iyaswamy, Di Xu, Senthilkumar Krishnamoorthi, Sravan Gopalkrishnashetty Sreenivasmurthy, Yuncong Yang, Yinhui Li, Chen Chen, Min Li, Hung-Wing Li and 1 more

Open access · hybridAbstract readReview
In one paragraph

Review in ACS applied materials & interfaces, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 57 citations in OpenAlex.

  1. Review
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  16. International journal of molecular sciences · 2022
    Article
  17. Targets and mechanisms ofFrontiers in aging neuroscience · 2022
    Article
  18. The role of TIGAR in nervous system diseases.Frontiers in aging neuroscience · 2022
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Xueli WangDepartment of Chemistry, Hong Kong Baptist University, 224 Waterloo Road, Kowloon Tong, Hong Kong, SAR 00000, China.
Ashok IyaswamyMr. & Mrs. Ko Chi-Ming Centre for Parkinson's Disease Research, School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong, SAR 00000, China.ORCID 0000-0003-0186-3863
Di XuDepartment of Chemistry, Hong Kong Baptist University, 224 Waterloo Road, Kowloon Tong, Hong Kong, SAR 00000, China.
Senthilkumar KrishnamoorthiMr. & Mrs. Ko Chi-Ming Centre for Parkinson's Disease Research, School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong, SAR 00000, China.
Sravan Gopalkrishnashetty SreenivasmurthyMr. & Mrs. Ko Chi-Ming Centre for Parkinson's Disease Research, School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong, SAR 00000, China.
Yuncong YangDepartment of Chemistry, Hong Kong Baptist University, 224 Waterloo Road, Kowloon Tong, Hong Kong, SAR 00000, China.
Yinhui LiDepartment of Chemistry, Hong Kong Baptist University, 224 Waterloo Road, Kowloon Tong, Hong Kong, SAR 00000, China.ORCID 0000-0002-3629-3656
Chen ChenDepartment of Chemistry, Hong Kong Baptist University, 224 Waterloo Road, Kowloon Tong, Hong Kong, SAR 00000, China.ORCID 0000-0001-7386-5812
Min LiMr. & Mrs. Ko Chi-Ming Centre for Parkinson's Disease Research, School of Chinese Medicine, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong, SAR 00000, China.
Hung-Wing LiDepartment of Chemistry, The Chinese University of Hong Kong, Room 243, Science Centre, North Block, Shatin, Hong Kong, SAR 00000, China.ORCID 0000-0003-4840-1965
Man Shing WongDepartment of Chemistry, Hong Kong Baptist University, 224 Waterloo Road, Kowloon Tong, Hong Kong, SAR 00000, China.ORCID 0000-0001-8141-9791
Hong Kong Baptist University · HKChinese University of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress, caused by an imbalance between the production and the accumulation of reactive oxygen species (ROS), is a prominent cause of the neurotoxicity induced by aggregated amyloid-β (Aβ) in Alzheimer's disease (AD). Tools that can directly detect and monitor the presence and amount of Aβ-induced ROS are still lacking. We report herein the first Aβ-targeted ratiometric H

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsBrainHydrogen PeroxideMiceMice, TransgenicReactive Oxygen SpeciesAmyloid beta-PeptidesHydrogen PeroxideReactive Oxygen SpeciesAlzheimer’s diseaseAβ-enhanced sensitivityAβ-targetingH2O2-responsive fluorescent probein-vivo detectionratiometric imaging

Identifiers

PMID35866616
PMCPMC9837777
OpenAlexW4286716539

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.