Evidence map›Paper›PMID 35866466›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022

Mesoporous Silica Materials as an Emerging Tool for Cancer Immunotherapy.

Blanca Escriche-Navarro, Andrea Escudero, Elena Lucena-Sánchez, Félix Sancenón, Alba García-Fernández, Ramón Martínez-Máñez

Open access · goldAbstract readReview
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 91 citations in OpenAlex.

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  15. Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Blanca Escriche-NavarroInteruniversity Research Institute for Molecular Recognition and Technological Development (IDM) Polytechnic University of Valencia-University of Valencia, Camino de Vera s/n, Valencia, 46022, Spain.
Andrea EscuderoInteruniversity Research Institute for Molecular Recognition and Technological Development (IDM) Polytechnic University of Valencia-University of Valencia, Camino de Vera s/n, Valencia, 46022, Spain.
Elena Lucena-SánchezInteruniversity Research Institute for Molecular Recognition and Technological Development (IDM) Polytechnic University of Valencia-University of Valencia, Camino de Vera s/n, Valencia, 46022, Spain.
Félix SancenónInteruniversity Research Institute for Molecular Recognition and Technological Development (IDM) Polytechnic University of Valencia-University of Valencia, Camino de Vera s/n, Valencia, 46022, Spain.
Alba García-FernándezInteruniversity Research Institute for Molecular Recognition and Technological Development (IDM) Polytechnic University of Valencia-University of Valencia, Camino de Vera s/n, Valencia, 46022, Spain.
Ramón Martínez-MáñezInteruniversity Research Institute for Molecular Recognition and Technological Development (IDM) Polytechnic University of Valencia-University of Valencia, Camino de Vera s/n, Valencia, 46022, Spain.ORCID 0000-0001-5873-9674
Universitat de València · ES

Funding

Conselleria d'Educació, Investigació, Cultura i Esport PROMETEO 2018/024European Union. A.E.Generalitat ValencianaGeneralitat Valenciana 2018/024Generalitat Valenciana PROMETEO/2018/024Ministerio de Ciencia, Innovación y Universidades RTI2018-101599-B-C22Spanish Government RTI2018-100910-B-C41Spanish Government RTI2018-101599-B-C22Spanish Instituto de Salud Carlos III (ISCIII) IFI19/00026
6 · The paper itself

Abstract

Cancer immunotherapy has emerged in the past decade as a promising strategy for treating many forms of cancer by stimulating the patient's immune system. Although immunotherapy has achieved some promising results in clinics, more efforts are required to improve the limitations of current treatments related to lack of effective and targeted cancer antigens delivery to immune cells, dose-limiting toxicity, and immune-mediated adverse effects, among others. In recent years, the use of nanomaterials has proven promising to enhance cancer immunotherapy efficacy and reduce side effects. Among nanomaterials, attention has been recently paid to mesoporous silica nanoparticles (MSNs) as a potential multiplatform for enhancing cancer immunotherapy by considering their unique properties, such as high porosity, and good biocompatibility, facile surface modification, and self-adjuvanticity. This review explores the role of MSN and other nano/micro-materials as an emerging tool to enhance cancer immunotherapy, and it comprehensively summarizes the different immunotherapeutic strategies addressed to date by using MSN.

Indexed as

NanoparticlesNeoplasmsDrug CarriersHumansImmunotherapySilicon DioxideDrug CarriersSilicon Dioxidecancercheckpoint inhibitorsimmunotherapymesoporous silica nanoparticlesphotodynamic therapiesvaccines

Identifiers

PMID35866466
PMCPMC9475525
OpenAlexW4286471987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.