Evidence map›Paper›PMID 35866442›Full record

ArticleMedical physics2022

Clinical acceptability of fully automated external beam radiotherapy for cervical cancer with three different beam delivery techniques.

Dong Joo Rhee, Anuja Jhingran, Kai Huang, Tucker J Netherton, Nazia Fakie, Ingrid White, Alicia Sherriff, Carlos E Cardenas, Lifei Zhang, Surendra Prajapati and 9 more

Open access · hybridAbstract read
In one paragraph

Article in Medical physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Evaluation of multiple-vendor AI autocontouring solutions.Radiation oncology (London, England) · 2024
    Article
  7. Automatic end-to-end VMAT treatment planning for rectal cancers.Journal of applied clinical medical physics · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 10 institutions in 3 countries.

Dong Joo RheeMedical Physics, The University of Texas Graduate School of Biomedical Sciences, at Houston, Houston, Texas, USA.
Anuja JhingranDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Kai HuangMedical Physics, The University of Texas Graduate School of Biomedical Sciences, at Houston, Houston, Texas, USA.
Tucker J NethertonDepartment of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Nazia FakieDivision of Radiation Oncology and Medical Physics, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa.
Ingrid WhiteRadiotherapy Department, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Alicia SherriffDepartment of Oncology, University of the Free State, Bloemfontein, South Africa.
Carlos E CardenasDepartment of Radiation Oncology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Lifei ZhangDepartment of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Surendra PrajapatiDepartment of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Stephen F KryDepartment of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Beth M BeadleDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA.
William ShawDepartment of Medical Physics (G68), University of the Free State, Bloemfontein, South Africa.
Frederika O'ReillyDepartment of Medical Physics (G68), University of the Free State, Bloemfontein, South Africa.
Jeannette ParkesDivision of Radiation Oncology and Medical Physics, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa.
Hester BurgerDivision of Radiation Oncology and Medical Physics, University of Cape Town and Groote Schuur Hospital, Cape Town, South Africa.
Chris TrauernichtDivision of Medical Physics, Tygerberg Academic Hospital, Stellenbosch University, Cape Town, South Africa.
Hannah SimondsDivision of Radiation Oncology, Tygerberg Academic Hospital, Stellenbosch University, Cape Town, South Africa.
Laurence E CourtDepartment of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
The University of Texas MD Anderson Cancer Center · USUniversity of Cape Town · ZAUniversity of the Free State · ZAGuy's and St Thomas' NHS Foundation Trust · GBStanford University · USStellenbosch University · ZATexas Medical Center · USThe University of Texas Health Science Center at Houston · USTygerberg Hospital · ZAUniversity of Alabama at Birmingham · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Scott Kopetz · 1985 to 2026
$290.8M
The Radiation Planning Assistant (RPA) for Radiation Therapy Planning in Low- and Middle-Income CountriesUH3CA202665 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BEADLE, BETH M, COURT, LAURENCE E · 2018 to 2020
$2.3M
The Radiation Planning Assistant (RPA) for Radiation Therapy Planning in Low- and Middle-Income CountriesUH2CA202665 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BEADLE, BETH M, COURT, LAURENCE E · 2016 to 2017
$953k
National Institutes of Health/National Cancer Institute P30-CA016672National Institutes of Health/National Cancer Institute UH2-CA202665National Institutes of Health/National Cancer Institute UH3-CA202665NCI NIH HHS P30 CA016672NCI NIH HHS UH2 CA202665NCI NIH HHS UH3 CA202665
6 · The paper itself

Abstract

purposeTo fully automate CT-based cervical cancer radiotherapy by automating contouring and planning for three different treatment techniques.

methodsWe automated three different radiotherapy planning techniques for locally advanced cervical cancer: 2D 4-field-box (4-field-box), 3D conformal radiotherapy (3D-CRT), and volumetric modulated arc therapy (VMAT). These auto-planning algorithms were combined with a previously developed auto-contouring system. To improve the quality of the 4-field-box and 3D-CRT plans, we used an in-house, field-in-field (FIF) automation program. Thirty-five plans were generated for each technique on CT scans from multiple institutions and evaluated by five experienced radiation oncologists from three different countries. Every plan was reviewed by two of the five radiation oncologists and scored using a 5-point Likert scale.

resultsOverall, 87%, 99%, and 94% of the automatically generated plans were found to be clinically acceptable without modification for the 4-field-box, 3D-CRT, and VMAT plans, respectively. Some customizations of the FIF configuration were necessary on the basis of radiation oncologist preference. Additionally, in some cases, it was necessary to renormalize the plan after it was generated to satisfy radiation oncologist preference.

conclusionApproximately, 90% of the automatically generated plans were clinically acceptable for all three planning techniques. This fully automated planning system has been implemented into the radiation planning assistant for further testing in resource-constrained radiotherapy departments in low- and middle-income countries.

Indexed as

Radiotherapy, ConformalRadiotherapy, Intensity-ModulatedUterine Cervical NeoplasmsFemaleHumansOrgans at RiskRadiotherapy DosageRadiotherapy Planning, Computer-Assistedauto-contouringauto-planningcervical cancerfield-in-field

Identifiers

PMID35866442
PMCPMC9474595
OpenAlexW4286470769

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.