ArticleStroke2022
Estimating Perfusion Deficits in Acute Stroke Patients Without Perfusion Imaging.
Article in Stroke, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Systemic inflammatory factors combined with HR-VWI-based plaque vulnerability discriminate ischemic phenotypes and predict prognosis in patients with intracranial atherosclerosis.Insights into imaging · 2026Article
- Retrospective cohort analysis of early post treatment follow-up MRI biomarkers of collateral status associated with long-term outcomes in large vessel occlusion acute ischemic stroke.Neuroradiology · 2026Article
- Review
- FLAIR Vascular Hyperintensities as Imaging Biomarker in Pediatric Acute Ischemic Stroke.Stroke · 2025Article
- Novel Insights into Viewer-Centered Versus Stimulus-Centered Hemispatial Neglect: A Cross-Sectional Behavioral and Imaging Study of Acute Stroke.Brain sciences · 2025Article
- Estimating the volume of penumbra in rodents using DTI and stack-based ensemble machine learning framework.European radiology experimental · 2024Article
- Location of Hyperintense Vessels on FLAIR Associated with the Location of Perfusion Deficits in PWI.Journal of clinical medicine · 2023Article
- FLAIR Vascular Hyperintensities as a Surrogate of Collaterals in Acute Stroke: DWI Matters.AJNR. American journal of neuroradiology · 2023Article
- Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundPerfusion weighted imaging (PWI) is critical for determining whether stroke patients presenting in an extended time window are candidates for mechanical thrombectomy. However, PWI is not always available. Fluid-attenuated inversion recovery hyperintense vessels (FHVs) are seen in patients with a PWI lesion. We investigated whether a scale measuring the extent FHV could serve as a surrogate for PWI to determine eligibility for thrombectomy.
methodsThe National Institutes of Health (NIH) FHV score was developed to quantify the burden of FHV and applied to magnetic resonance imaging scans of stroke patients with fluid-attenuated inversion recovery and perfusion imaging. The NIH-FHV was combined with the diffusion weighted image volume to estimate the diffusion-perfusion mismatch ratio. Linear regression was used to compare PWI volumes and mismatch ratios with estimates from the NIH-FHV score. Receiver operating characteristic analysis was used to test the ability of the NIH-FHV score to identify a significant mismatch.
resultsThere were 101 patients included in the analysis, of whom 78% had a perfusion deficit detected on PWI with a mean lesion volume of 47 (±59) mL. The NIH-FHV score was strongly associated with the PWI lesion volume (
conclusionsThe NIH-FHV score provides an estimate of the PWI lesion volume and, when combined with diffusion weighted imaging, may be helpful when trying to determine whether there is a clinically relevant diffusion-perfusion mismatch in situations where perfusion imaging is not available. Further studies are needed to validate this approach.
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