Evidence map›Paper›PMID 35866206›Full record

Trial reportClinical rehabilitation2022

Post stroke intervention trial in fatigue (POSITIF): Randomised multicentre feasibility trial.

Gillian Mead, David Gillespie, Mark Barber, Allan House, Steff Lewis, Hannah Ensor, Simiao Wu, Trudie Chalder

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03551327 (POst Stroke Intervention Trial in Fatigue), which is not on this map. Cited by 10 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03551327 nacompletednot on this map

POst Stroke Intervention Trial in Fatigue: A Randomised Controlled Trial of a Brief Intervention for Post-stroke Fatigue

TypeinterventionalSponsorUniversity of EdinburghRan2018 to 2021Enrolled76ConditionsPost-stroke FatigueArmsExperimental: Intervention plus information, Active Comparator: Information only
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Gillian MeadUsher institute, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-7494-2023
David GillespieDepartment of Clinical Neurosciences, Royal Infirmary of Edinburgh, Edinburgh, UK.ORCID 0000-0003-1325-9727
Mark BarberNHS Lanarkshire, 4468University Hospital Monklands, Coatbridge, UK.
Allan HouseLeeds Institute of Health Sciences, Leeds, UK.
Steff LewisEdinburgh Clinical Trials Unit, University of Edinburgh, Edinburgh, UK.
Hannah EnsorEdinburgh Clinical Trials Unit, University of Edinburgh, Edinburgh, UK.
Simiao WuDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Trudie ChalderDepartment of Psychological Medicine, Kings College London, London, UK.

Funding

TOXIC AND ESSENTIAL METALSP30ES000159 · NIEHS · UNIVERSITY OF CINCINNATI · PI ALBERT, ROY E · 1985 to 1991
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NIEHS NIH HHS P30 ES000159
6 · The paper itself

Abstract

objectiveTo test the feasibility of a telephone delivered intervention, informed by cognitive behavioural principles, for post-stroke fatigue, and estimated its effect on fatigue and other outcomes.

designRandomised controlled parallel group trial.

settingThree Scottish stroke services. SUBJECTS: Stroke survivors with fatigue three months to two years post-stroke onset.

interventionsSeven telephone calls (fortnightly then a 'booster session' at 16 weeks) of a manualised intervention, plus information about fatigue, versus information only. MAIN MEASURES: Feasibility of trial methods, and collected outcome measures (fatigue, mood, anxiety, social participation, quality of life, return to work) just before randomisation, at the end of treatment (four months after randomisation) and at six months after randomisation.

resultsBetween October 2018 and January 2020, we invited 886 stroke survivors to participate in postal screening: 188/886 (21%) returned questionnaires and consented, of whom 76/188 (40%) were eligible and returned baseline forms; 64/76 (84%) returned six month follow-up questionnaires. Of the 39 allocated the intervention, 23 (59%) attended at least four sessions. At six months, there were no significant differences between the groups (adjusted mean differences in Fatigue Assessment Scale -0.619 (95% CI -4.9631, 3.694;

conclusionPatients can be recruited to a trial of this design. These data will inform the design of further trials in post-stroke fatigue.

Indexed as

FatigueStrokeFeasibility StudiesHumansQuality of LifeFatiguerandomized controlled trialstroke

Identifiers

PMID35866206
PMCPMC9574032

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.