Evidence map›Paper›PMID 35866193›Full record

ArticleAngewandte Chemie (International ed. in English)2022

Chemical Investigations of Differentially Oxidized Polycylic Pyrroles from Bipolaris Fungi: Synthetic Entry Into the Bipolamine Alkaloids.

Jun Xuan, Paulo A Machicao, Karl T Haelsig, Thomas J Maimone

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 61% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jun XuanDepartment of Chemistry, University of California, Berkeley, 826 Latimer Hall, Berkeley, CA 94720, USA.
Paulo A MachicaoDepartment of Chemistry, University of California, Berkeley, 826 Latimer Hall, Berkeley, CA 94720, USA.
Karl T HaelsigDepartment of Chemistry, University of California, Berkeley, 826 Latimer Hall, Berkeley, CA 94720, USA.
Thomas J MaimoneDepartment of Chemistry, University of California, Berkeley, 826 Latimer Hall, Berkeley, CA 94720, USA.ORCID 0000-0001-5823-692X
University of California, Berkeley · US

Funding

Chemical Synthesis and Biology of Complex AlkaloidsR01GM136945 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI MAIMONE, THOMAS JOHN, NOMURA, DANIEL · 2020 to 2023
$2.0M
Acquisition of a Cryoprobe and Related Accessories for a 600 MHz NMR Spectrometer to Support Health Research Activities at the University of California, BerkeleyS10OD024998 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI HARTWIG, JOHN F · 2018 to 2018
$265k
NIGMS NIH HHS R01 GM136945NIH HHS S10 OD024998
6 · The paper itself

Abstract

indolizidine alkaloids of unusual biosynthetic origin have recently been characterized from several species of fungi within the Pleosporaceae family. Possessing distinct polycyclic architectures with two embedded electron-rich pyrroles as well as reported antibacterial activity against gram positive and negative pathogens, these natural products represent attractive targets for total synthesis. Herein we survey the differential functionalization of a chemically sensitive bispyrrole framework resulting in the preparation of multiple bipolamine alkaloids, work which sheds light on their innate chemical reactivity and potential biosynthetic relationships.

Indexed as

AlkaloidsAscomycotaBiological ProductsBipolarisPyrrolesAlkaloidsBiological ProductsPyrrolesalkaloidsantibioticsnatural productspyrrolestotal synthesis

Identifiers

PMID35866193
PMCPMC9452474
OpenAlexW4286447965

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.