ArticleEcology and evolution2022
Methodological confounds of measuring urinary oxidative stress in wild animals.
Article in Ecology and evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Effects of storage conditions on oxidative stress biomarkers: methodological implications for ecological and evolutionary studies.The Journal of experimental biology · 2026Article
- Assessment of Oxidative Stress and Biometric Data in a Captive Colony of Hamadryas Baboons (Veterinary sciences · 2025Article
- Diurnal Variation of 8-hydroxy-2'-deoxyguanosine in Continuous Time Series of Two Breast Cancer Survivors.Journal of circadian rhythms · 2025Article
- Ecological generalism and physiology mediate fish biogeographic ranges under ocean warming.Proceedings. Biological sciences · 2024Article
- Heat-shock proteins, oxidative stress, and antioxidants in one-humped camels.Tropical animal health and production · 2023Article
- Stress in wildlife: comparison of the stress response among domestic, captive, and free-ranging animals.Frontiers in veterinary science · 2023Review
- Methodological confounds of measuring urinary oxidative stress in wild animals.Ecology and evolution · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biomarkers of oxidative stress (OS) are useful in addressing a wide range of research questions, but thus far, they have had limited application to wild mammal populations due to a reliance on blood or tissue sampling. A shift toward non-invasive measurement of OS would allow field ecologists and conservationists to apply this method more readily. However, the impact of methodological confounds on urinary OS measurement under field conditions has never been explicitly investigated. We combined a cross-sectional analysis with a field experiment to assess the impact of four potential methodological confounds on OS measurements: (1) time of sampling, (2) environmental contamination from foliage; (3) delay between sample collection and flash-freezing in liquid nitrogen; and (4) sample storage of up to 15 months below -80°C. We measured DNA oxidative damage (8-hydroxy-2'-deoxyguanosine, 8-OHdG), lipid peroxidation (malondialdehyde, MDA), total antioxidant capacity (TAC), and uric acid (UA) in 167 urine samples collected from wild Zanzibar red colobus (
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