ArticleFrontiers in cellular and infection microbiology2022
The Gastrointestinal Load of Carbapenem-Resistant Enterobacteriacea Is Associated With the Transition From Colonization to Infection by
Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- The Association Between Antibiotic Use and the Incidence of Third-Generation Cephalosporin-Resistance inAntibiotics (Basel, Switzerland) · 2026Article
- COVID-19 pandemic-driven evolution of Klebsiella pneumoniae: rising resistance, genetic diversity, and virulence in a Brazilian tertiary hospital.Einstein (Sao Paulo, Brazil) · 2026Article
- Asymptomatic faecal carriage of vancomycin-resistant Enterococci among inpatients and outpatients in a Kenyan hospital: a cross-sectional study.Antimicrobial resistance and infection control · 2025Article
- Risk Factors and Molecular Epidemiology of Infections Among Patients with Intestinal Colonization by Carbapenem-ResistantInfection and drug resistance · 2025Article
- Multiplexed real-time PCR for the detection and differentiation ofMicrobiology spectrum · 2024Article
- Evaluation of the Xpert Carba-R assay for quantifying carbapenemase-producing bacterial load in stool samples.PloS one · 2024Article
- Emergence of KPC-113 and KPC-114 variants in ceftazidime-avibactam-resistantMicrobiology spectrum · 2023Article
- Hospital sanitary facilities on wards with high antibiotic exposure play an important role in maintaining a reservoir of resistant pathogens, even over many years.Antimicrobial resistance and infection control · 2023Article
- Prevalence of intestinal colonization and nosocomial infection with carbapenem-resistantFrontiers in public health · 2023Article
- Intestinal loads of extended-spectrum beta-lactamase and Carbapenemase genes in critically ill pediatric patients.Frontiers in cellular and infection microbiology · 2023Article
- Bloodstream Infections in Patients with Rectal Colonization by Carbapenem-Resistant Enterobacteriaceae: A Prospective Cohort Study.Infection and drug resistance · 2022Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Healthcare-associated infections by carbapenem-resistant Objective: We investigated the transition from carriage to infection by Methods: KpKPC isolates detected within a 10-year period in a single tertiary-care hospital were characterized by pulsed-field gel electrophoresis (PFGE), multilocus sequencing typing, capsular lipopolysaccharide and polysaccharide typing, antimicrobial susceptibility profiles, and the presence of virulence genes. The gastrointestinal load of carbapenem-resistant Enterobacteriaceae and of Results: No PGFE type; ST-, K-, or O-serotypes; antimicrobial susceptibility profiles; or the presence of virulence markers, such yersiniabactin and colibactin, were associated with carriage or infection, with ST437 and ST11 being the most prevalent clones. Admission to intensive and semi-intensive care units was a risk factor for the development of infections (OR 2.79, 95% CI 1.375 to 5.687, Conclusion: The presence of resistance and virulence mechanisms were not associated with progression from colonization to infection, while intestinal colonization by carbapenem-resistant Enterobacteriacea and, more specifically, the load of gastrointestinal carriage emerged as an important determinant of infection.
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