Evidence map›Paper›PMID 35865779›Full record

ArticleClinical case reports2022

Genomic and immune microenvironment profiling in a case of metastatic intrathyroid thymic carcinoma.

Hiroki Ishii, Takahiro Tsujikawa, Naoki Oishi, Arisa Kinouchi, Kaname Sakamoto, Junichi Mitsuda, Hiroshi Ogi, Kyoko Itoh, Tetsuo Kondo, Shigeru Hirano and 1 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Hiroki IshiiDepartment of Otolaryngology, Head and Neck Surgery University of Yamanashi Chuo Japan.ORCID https://orcid.org/0000-0003-1329-2180
Takahiro TsujikawaDepartment of Otolaryngology-Head and Neck Surgery Kyoto Prefectural University of Medicine Kyoto Japan.
Naoki OishiDepartment of pathology, Interdisciplinary Graduate School of Medicine University of Yamanashi Chuo Japan.
Arisa KinouchiDepartment of Otolaryngology, Head and Neck Surgery University of Yamanashi Chuo Japan.
Kaname SakamotoDepartment of Otolaryngology, Head and Neck Surgery University of Yamanashi Chuo Japan.
Junichi MitsudaDepartment of Otolaryngology-Head and Neck Surgery Kyoto Prefectural University of Medicine Kyoto Japan.
Hiroshi OgiDepartment of Pathology and Applied Neurobiology Kyoto Prefectural University of Medicine Kyoto Japan.
Kyoko ItohDepartment of Pathology and Applied Neurobiology Kyoto Prefectural University of Medicine Kyoto Japan.
Tetsuo KondoDepartment of pathology, Interdisciplinary Graduate School of Medicine University of Yamanashi Chuo Japan.
Shigeru HiranoDepartment of Otolaryngology-Head and Neck Surgery Kyoto Prefectural University of Medicine Kyoto Japan.
Daiju SakuraiDepartment of Otolaryngology, Head and Neck Surgery University of Yamanashi Chuo Japan.
University of Yamanashi · JPKyoto Prefectural University of Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metastatic intrathyroid thymic carcinoma (ITTC) is a rare cancer with no effective drugs for controlling. This case report has shown genomic and immune microenvironment profiles in metastatic ITTC and emphasized an immunosuppression via a PD-1/PD-L1 pathway, possibly strengthening the rationale for immune checkpoint blockade as a novel treatment.

Indexed as

immune checkpoint inhibitorintrathyroid thymic carcinomamutation analysisPD‐1/PD‐L1tumor‐immune microenvironment

Identifiers

PMID35865779
PMCPMC9290770
OpenAlexW4285735738

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.