Evidence map›Paper›PMID 35865749›Full record

ArticleFrontiers in aging neuroscience2022

Abnormalities in the Fractional Amplitude of Low-Frequency Fluctuation and Functional Connectivity in Parkinson's Disease With Excessive Daytime Sleepiness.

Yuheng Zi, Sainan Cai, Changlian Tan, Tianyu Wang, Qin Shen, Qinru Liu, Min Wang, Junli Li, Lin Zhang, Fan Zhou and 5 more

Abstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Relationship between excessive daytime sleepiness and motor subtype transition in untreated prodromal Parkinson's disease: a cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yuheng ZiDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Sainan CaiDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Changlian TanDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Tianyu WangDepartment of Radiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Qin ShenDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Qinru LiuDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Min WangDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Junli LiDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Lin ZhangDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Fan ZhouDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Chendie SongDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Jiaying YuanDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Yujing LiuDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Jun LiuDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.
Haiyan LiaoDepartment of Radiology, The Second Xiangya Hospital, Central South University, Changsha, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Excessive daytime sleepiness (EDS) is one of the most important non-motor symptoms of Parkinson's disease (PD), and its neuropathologic basis is still unclear. Objective: This study investigated the changes of neuronal activity in PD patients with EDS (PD-EDS) in the resting state. Methods: Forty-three PD patients were recruited and divided into the PD-EDS group ( Results: PD-EDS patients exhibited a decreased fALFF in the Cingulum-Ant-R, but an increased fALFF in the Putamen-R and Thalamus-L when compared with PD-NEDS patients; an increased functional connectivity between these three seed regions with different fALFF values and the right medial frontal gyrus, bilateral superior temporal gyrus, left insular, and right precuneus was observed ( Conclusions: EDS in PD patients may be associated with changes in brain neuron activity and functional connectivity.

Indexed as

excessive daytime sleepiness (EDS)fractional amplitude of low-frequency fluctuationfunctional connectivity (FC)Parkinson's diseaseresting-state functional MRI (rs-fMRI)

Identifiers

PMID35865749
PMCPMC9294344

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.