Evidence map›Paper›PMID 35865666›Full record

ArticleBioMed research international2022

Betamethasone Dipropionate Derivatization, Biotransformation, Molecular Docking, and ADME Analysis as Glucocorticoid Receptor.

Sana Rashid, Shazia Anjum, Aqeel Ahmad, Raziya Nadeem, Maqsood Ahmed, Syed Adnan Ali Shah, Muhammad Abdullah, Komal Zia, Zaheer Ul-Haq

RetractedOpen access · hybridAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Sana RashidInstitute of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.ORCID https://orcid.org/0000-0001-5338-9492
Shazia AnjumInstitute of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.ORCID https://orcid.org/0000-0001-9660-3057
Aqeel AhmadUniversity of Chinese Academy of Science (UCAS), Beijing, China.ORCID https://orcid.org/0000-0001-9097-2628
Raziya NadeemDepartment of Chemistry, University of Agriculture, Faisalabad, Pakistan.ORCID https://orcid.org/0000-0003-0893-4265
Maqsood AhmedMaterial Chemistry Lab, Institute of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.ORCID https://orcid.org/0000-0002-9700-3819
Syed Adnan Ali ShahFaculty of Pharmacy, Atta-ur-Rahman Institute for Natural Products Discovery, Universiti Teknologi MARA, Cawangan Selangor Kampus Puncak Alam, 42300 Bandar Puncak Alam, Selangor D. E, Malaysia.ORCID https://orcid.org/0000-0002-8142-5013
Muhammad AbdullahCholistan Institute of Desert Studies, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.ORCID https://orcid.org/0000-0002-4491-6657
Komal ZiaDr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.ORCID https://orcid.org/0000-0003-3554-1934
Zaheer Ul-HaqDr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.ORCID https://orcid.org/0000-0002-8530-8711
Islamia University of Bahawalpur · PKUniversity of Karachi · PKUniversiti Teknologi MARA · MYUniversity of Agriculture Faisalabad · PKUniversity of Chinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Betamethasone is an important glucocorticoids (GCs), frequently used to cure allergies (such as asthma and angioedema), Crohn's disease, skin diseases (such as dermatitis and psoriasis), systemic lupus erythematosus, rheumatic disorders, and leukemia. Present investigation deals to find potential agonist of glucocorticoid receptors after biotransformation of betamethasone dipropionate (1) and to carry out the molecular docking and ADME analyses. Biotransformation of 1 was carried out with

Indexed as

Dermatologic AgentsPsoriasisBetamethasoneBiotransformationHumansMolecular Docking SimulationReceptors, GlucocorticoidBetamethasonebetamethasone-17,21-dipropionateDermatologic AgentsReceptors, Glucocorticoid

Identifiers

PMID35865666
PMCPMC9296322
OpenAlexW4286768696

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.