Evidence map›Paper›PMID 35865648›Full record

ArticleEngineering in life sciences2022

Novel bioreactor internals for the cultivation of spore-forming fungi in pellet form.

Winda Soerjawinata, Isabelle Kockler, Lars Wommer, Robert Frank, Anja Schüffler, Tanja Schirmeister, Roland Ulber, Percy Kampeis

Abstract read
In one paragraph

Article in Engineering in life sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Pelletized Growth inJournal of fungi (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Production of Protease Inhibitor WithEngineering in life sciences · 2025
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Winda SoerjawinataInstitute for Biotechnical Process Design Trier University of Applied Sciences, Environmental Campus Birkenfeld Hoppstädten-Weiersbach Germany.
Isabelle KocklerInstitute for Biotechnical Process Design Trier University of Applied Sciences, Environmental Campus Birkenfeld Hoppstädten-Weiersbach Germany.
Lars WommerInstitute for Biotechnical Process Design Trier University of Applied Sciences, Environmental Campus Birkenfeld Hoppstädten-Weiersbach Germany.
Robert FrankInstitute for Biotechnical Process Design Trier University of Applied Sciences, Environmental Campus Birkenfeld Hoppstädten-Weiersbach Germany.
Anja SchüfflerInstitut für Biotechnologie und Wirkstoff-Forschung gGmbH (IBWF) Mainz Germany.
Tanja SchirmeisterInstitute of Pharmaceutical and Biomedical Sciences Johannes Gutenberg University of Mainz Mainz Germany.
Roland UlberInstitute of Bioprocess Engineering Technical University Kaiserslautern Kaiserslautern Germany.ORCID https://orcid.org/0000-0002-7674-0967
Percy KampeisInstitute for Biotechnical Process Design Trier University of Applied Sciences, Environmental Campus Birkenfeld Hoppstädten-Weiersbach Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study introduced an automated long-term fermentation process for fungals grown in pellet form. The goal was to reduce the overgrowth of bioreactor internals and sensors while better rheological properties in the fermentation broth, such as oxygen transfer and mixing time, can be achieved. Because this could not be accomplished with continuous culture and fed-batch fermentation, repeated-batch fermentation was implemented with the help of additional bioreactor internals ("sporulation supports"). This should capture some biomass during fermentation. After harvesting the suspended biomass, intermediate cleaning was performed using a cleaning device. The biomass retained on the sporulation support went through the sporulation phase. The spores were subsequently used as inocula for the next batch. The reason for this approach was that the retained pellets could otherwise cause problems (

Indexed as

bioreactor internalsfungal growthfungal pelletsrepeated‐batch fermentationsporulation conditions

Identifiers

PMID35865648
PMCPMC9288991

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.